Edited GRIK2 (GluR6) [plasma membrane]

Stable Identifier
R-HSA-451318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General

GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.

External Reference Information
External Reference
Gene Names
GRIK2, GLUR6
Chain
signal peptide:1-31, chain:32-908
Other Identifiers
0002970440
0003130176
0105570427
11741955_a_at
11746867_a_at
11758524_s_at
1560142_at
1563754_at
17011217
213845_at
2898
2918986
2918987
2919001
2919002
2919003
2919016
2919017
2919018
2919032
2919033
2919036
2919037
2919042
2919044
2919045
2919057
2919062
2919063
2919080
2919082
2919084
2919085
2919087
2919088
2919089
2919090
3928259
39572_at
39573_at
8121225
A_14_P108416
A_14_P139842
A_23_P250136
A_24_P935839
A_32_P115796
A_33_P3307133
A_33_P3307144
A_33_P3307147
GE82629
GO:0001662
GO:0003674
GO:0004970
GO:0005216
GO:0005234
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006811
GO:0006874
GO:0006950
GO:0007165
GO:0007215
GO:0007267
GO:0007268
GO:0008066
GO:0008150
GO:0008219
GO:0008328
GO:0014069
GO:0015276
GO:0015277
GO:0016020
GO:0016021
GO:0019228
GO:0019899
GO:0022857
GO:0030054
GO:0030165
GO:0030424
GO:0030425
GO:0031624
GO:0031625
GO:0032839
GO:0032983
GO:0032991
GO:0034220
GO:0035235
GO:0035249
GO:0038023
GO:0042391
GO:0042592
GO:0042734
GO:0042802
GO:0043025
GO:0043113
GO:0043195
GO:0043204
GO:0043226
GO:0043524
GO:0043525
GO:0045202
GO:0045211
GO:0046328
GO:0048169
GO:0048172
GO:0050804
GO:0050806
GO:0050877
GO:0051402
GO:0051967
GO:0055085
GO:0060079
GO:0060080
GO:0098686
GO:0098978
GO:0099505
GO:0099507
GO:0120169
GO:1904315
Hs.301676.0.S2_3p_at
Hs2.301676.4.S1_3p_at
Hs2.301676.4.S1_3p_s_at
Hs2.301676.5.S1_3p_at
Hs2.301676.5.S1_3p_x_at
ILMN_1661376
ILMN_1666934
ILMN_2396697
ILMN_2396702
PH_hs_0023669
TC06000836.hg
U16126_at
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
L-glutamine 621 replaced with L-arginine
Coordinate
621
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-arginine.
A protein modification that effectively removes or replaces an L-glutamine.
Name
3-(S-L-cysteinyl)-L-tyrosine at 571
Coordinate
571
PsiMod Name
PsiMod Definition
A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine.
Name
L-isoleucine 567 replaced with L-valine
Coordinate
567
PsiMod
A protein modification that effectively removes or replaces an L-isoleucine.
A protein modification that effectively converts a source amino acid residue to an L-valine.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Metabolites
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
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