Edited GRIK2 (GluR6) [plasma membrane]

Stable Identifier
R-HSA-451318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.
External Reference Information
External Reference
UniProt:Q13002 GRIK2
Gene Names
GRIK2, GLUR6
Chain
signal peptide:1-31, chain:32-908
Reference Genes
BioGPS Gene:2898 GRIK2
COSMIC (genes):GRIK2 GRIK5
CTD Gene:2898 Q8IY40
dbSNP Gene:2898 Q8IY40
ENSEMBL:ENSG00000164418 GRIK2
HGNC:4580 GRIK2
KEGG:hsa:2898 GRIK2
Monarch:2898 GRIK2
NCBI Gene:2898 GRIK2
OMIM:138244 GRIK2
UCSC:Q13002 GRIK2
Reference Transcript
Other Identifiers
11741955_a_at
11746867_a_at
11758524_s_at
11762583_at
11762584_x_at
1555375_PM_at
1555375_at
1560142_PM_at
1560142_at
1560265_3p_at
1560265_PM_at
1560265_at
1563754_PM_at
1563754_at
17011217
213845_PM_at
213845_at
215655_PM_at
215655_at
2898
2918947
2918981
2918983
2918984
2918986
2918987
2919001
2919002
2919003
2919016
2919017
2919018
2919029
2919032
2919033
2919036
2919037
2919042
2919044
2919045
2919046
2919047
2919048
2919049
2919056
2919057
2919058
2919059
2919060
2919061
2919062
2919063
2919068
2919072
2919080
2919081
2919082
2919083
2919084
2919085
2919087
2919088
2919089
2919090
3928259
39572_at
39573_at
8121225
A_14_P105881
A_14_P108416
A_14_P139842
A_23_P250136
A_24_P935839
A_32_P115796
A_33_P3307133
A_33_P3307144
A_33_P3307147
GE493132
GE82629
GO:0000149
GO:0001662
GO:0004970
GO:0005215
GO:0005216
GO:0005234
GO:0005886
GO:0006811
GO:0006874
GO:0007215
GO:0007268
GO:0008066
GO:0008328
GO:0012501
GO:0014069
GO:0015276
GO:0015277
GO:0016020
GO:0019228
GO:0022849
GO:0023052
GO:0030165
GO:0030424
GO:0030425
GO:0031624
GO:0031625
GO:0032839
GO:0032983
GO:0034220
GO:0035235
GO:0035249
GO:0038023
GO:0042391
GO:0042734
GO:0042802
GO:0043025
GO:0043113
GO:0043195
GO:0043204
GO:0043226
GO:0043524
GO:0043525
GO:0045202
GO:0045211
GO:0046328
GO:0048169
GO:0048172
GO:0050804
GO:0050806
GO:0051402
GO:0051967
GO:0055085
GO:0060079
GO:0060080
GO:0060089
GO:0097110
GO:0097471
GO:0098686
GO:0098815
GO:0098839
GO:0098978
GO:0099171
GO:0099505
GO:0099507
GO:0120169
GO:1904315
HMNXSV003019918
HMNXSV003056832
Hs.301676.0.S2_3p_at
Hs.306651.0.S1_3p_at
Hs2.301676.2.S1_3p_at
Hs2.301676.4.S1_3p_at
Hs2.301676.4.S1_3p_s_at
Hs2.301676.5.S1_3p_at
Hs2.301676.5.S1_3p_x_at
Hs2.420694.1.A1_3p_at
Hs2.420694.1.A1_3p_s_at
Hs2.420694.1.A1_3p_x_at
ILMN_1661376
ILMN_1666934
ILMN_2396697
ILMN_2396702
PH_hs_0023669
TC06000836.hg
TC06002957.hg
U16126_at
Participates
as a component of
Other forms of this molecule
GRIK2 [plasma membrane]
Inferred To
GluRIIA [plasma membrane] (Drosophila melanogaster)
Edited GRIK2 (GluR6) [plasma membrane] (Bos taurus)
Edited GRIK2 (GluR6) [plasma membrane] (Canis familiaris)
Edited GRIK2 (GluR6) [plasma membrane] (Drosophila melanogaster)
Edited GRIK2 (GluR6) [plasma membrane] (Gallus gallus)
Edited GRIK2 (GluR6) [plasma membrane] (Mus musculus)
Edited GRIK2 (GluR6) [plasma membrane] (Rattus norvegicus)
Edited GRIK2 (GluR6) [plasma membrane] (Sus scrofa)
Homologues of Edited GRIK2 (GluR6) [plasma membrane] (Drosophila melanogaster)
Modified Residues
Name
L-glutamine 621 replaced with L-arginine
Coordinate
621
PsiMod
L-glutamine removal [MOD:01637]
A protein modification that effectively removes or replaces an L-glutamine.
L-arginine residue [MOD:00011]
A protein modification that effectively converts a source amino acid residue to an L-arginine.
Name
3-(S-L-cysteinyl)-L-tyrosine at 571
Coordinate
571
PsiMod Name
3-(S-L-cysteinyl)-L-tyrosine [MOD:00803]
PsiMod Definition
A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine.
Name
L-isoleucine 567 replaced with L-valine
Coordinate
567
PsiMod
L-valine residue [MOD:00029]
A protein modification that effectively converts a source amino acid residue to an L-valine.
L-isoleucine removal [MOD:01640]
A protein modification that effectively removes or replaces an L-isoleucine.
Cross References
Guide to Pharmacology - Targets
451
OpenTargets
ENSEMBL
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
GlyGen
PDB
ZINC - Metabolites
HPA
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
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