Edited GRIK2 (GluR6) [plasma membrane]

Stable Identifier
R-HSA-451318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General

GRIK2 is edited at the Q/R site at 621 where the glutamine is edited to arginine. GRIK2 is also edited at 571 (Y/C) where a tyrosine residue is changed to cysteine and 567 (I/V) where an isoleucine is changed to valine. All three sites are edited postranscriptionally. A fully edited GRIK2 at all three sites is totally impermeable to calcium ions.

External Reference Information
External Reference
Gene Names
GRIK2, GLUR6
Chain
signal peptide:1-31, chain:32-908
Other Identifiers
0002970440
0003130176
0105570427
11741955_a_at
11746867_a_at
11758524_s_at
14395
14623
1560142_at
1563754_at
17011217
213845_at
22463
2898
2918986
2918987
2919001
2919002
2919003
2919016
2919017
2919018
2919032
2919033
2919036
2919037
2919042
2919044
2919045
2919057
2919062
2919063
2919080
2919082
2919084
2919085
2919087
2919088
2919089
2919090
3928259
39572_at
39573_at
3QXM
5CMM
8121225
A0A0A0MR30
A0A0A0MRL4
A_14_P108416
A_14_P139842
A_23_P250136
A_24_P935839
A_32_P115796
A_33_P3307133
A_33_P3307144
A_33_P3307147
AAC50420
ADH93569
ADH93570
ADH93571
ADH93572
ADH93573
AJ252246
AJ301608
AJ301609
AJ301610
AL109919
AP002528
AP002529
AP002530
CAB022463
CAC67485
CAC67486
CAC67487
CAC81020
CCDS5048
CCDS5049
CCDS55045
CH471051
EAW48448
ENSG00000164418
ENSP00000358134
ENSP00000397026
ENSP00000405596
ENST00000369138
ENST00000369138.5
ENST00000413795
ENST00000413795.5
ENST00000421544
ENST00000421544.6
EntrezGene:2898
EntrezGene:GRIK2
F8WEZ8
G3XAD3
GE82629
GO:0001662
GO:0003674
GO:0004970
GO:0005216
GO:0005234
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0006811
GO:0006874
GO:0006950
GO:0007165
GO:0007215
GO:0007267
GO:0007268
GO:0008066
GO:0008150
GO:0008219
GO:0008328
GO:0014069
GO:0015277
GO:0016020
GO:0016021
GO:0019228
GO:0019899
GO:0022857
GO:0030054
GO:0030165
GO:0030424
GO:0030425
GO:0031624
GO:0031625
GO:0032839
GO:0032983
GO:0032991
GO:0034220
GO:0035235
GO:0035249
GO:0038023
GO:0042391
GO:0042592
GO:0042734
GO:0042802
GO:0042803
GO:0043025
GO:0043113
GO:0043195
GO:0043204
GO:0043226
GO:0043524
GO:0043525
GO:0045202
GO:0045211
GO:0046328
GO:0048169
GO:0048172
GO:0050804
GO:0050806
GO:0050877
GO:0051402
GO:0051967
GO:0055085
GO:0060079
GO:0060080
GO:0098686
GO:0098978
GO:0099505
GO:0099507
GO:1904315
GRIK2
GRIK2-205
GRIK2-206
GRIK2-207
H7BZX7
H7C2P5
HGNC:4580
HM149335
HM149336
HM149337
HM149338
HM149339
HPA014395
HPA014623
Hs.301676.0.S2_3p_at
Hs2.301676.4.S1_3p_at
Hs2.301676.4.S1_3p_s_at
Hs2.301676.5.S1_3p_at
Hs2.301676.5.S1_3p_x_at
ILMN_1661376
ILMN_1666934
ILMN_2396697
ILMN_2396702
IPR001320
IPR001508
IPR001828
IPR019594
IPR028082
MIM:138244
MIM:611092
NM_001166247
NM_021956
NM_175768
NP_001159719
NP_068775
NP_786944
PF00060
PF01094
PF10613
PH_hs_0023669
PR00177
SM00079
SM00918
TC06000836.hg
U16126
U16126_at
UPI000006DFF5
UPI000012B617
UPI000059D903
XM_005266945
XM_011535777
XM_017010781
XM_017010782
XM_024446410
XM_024446411
XP_005267002
XP_011534079
XP_016866270
XP_016866271
XP_024302178
XP_024302179
XR_002956278
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name
L-glutamine 621 replaced with L-arginine
Coordinate
621
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-arginine.
A protein modification that effectively removes or replaces an L-glutamine.
Name
3-(S-L-cysteinyl)-L-tyrosine at 571
Coordinate
571
PsiMod Name
PsiMod Definition
A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine.
Name
L-isoleucine 567 replaced with L-valine
Coordinate
567
PsiMod
A protein modification that effectively removes or replaces an L-isoleucine.
A protein modification that effectively converts a source amino acid residue to an L-valine.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Metabolites
GeneCards
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein