Reactome | Protein Kinase B/Akt phosphorylates BRF1

Protein Kinase B/Akt phosphorylates BRF1

Stable Identifier

R-HSA-450490

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Protein Kinase B/Akt phosphorylates BRF1

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BRF1 is phosphorylated at Serine92 and Serine203 by Protein kinase B/AKT. Protein kinase B is activated by phosphatidylinositol 3-kinase. Phosphorylation of BRF1 does not interfere with the ability of BRF1 to bind RNA or interact with enzymes that catalyze RNA degradation therefore larger complexes may contain phosphorylated BRF1.

Literature References

PubMed ID	Title	Journal	Year
17030608	BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites Benjamin, D, Schmidlin, M, Min, L, Gross, B, Moroni, C	Mol Cell Biol	2006
15538381	The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B Schmidlin, M, Lu, M, Leuenberger, SA, Stoecklin, G, Mallaun, M, Gross, B, Gherzi, R, Hess, D, Hemmings, BA, Moroni, C	EMBO J	2004
12198173	Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover Stoecklin, G, Colombi, M, Raineri, I, Leuenberger, S, Mallaun, M, Schmidlin, M, Gross, B, Lu, M, Kitamura, T, Moroni, C	EMBO J	2002