Reactome | MK2 phosphorylates BRF1

MK2 phosphorylates BRF1

Stable Identifier

R-HSA-450474

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at serine 54, serine 92, serine 203, and an unknown site in the C terminus. Phosphorylation inhibits the ability of BRF1 to cause degradation of RNA. It is unknown if tetraphosphorylated BRF1 binds 14-3-3 in the same way as diphosphorylated BRF1 does.

Literature References

PubMed ID	Title	Journal	Year
18326031	The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2 Maitra, S, Chou, CF, Luber, CA, Lee, KY, Mann, M, Chen, CY	RNA	2008