AUF1:mRNA complex is destroyed

Stable Identifier
R-HSA-450466
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Ubiquitin-dependent proteolysis of AUF1 and nuclease-dependent destruction of AUF1-bound mRNA are coupled in an unknown way. It is possible that ubiquitinated AUF1 targets other members of the AUF1 and signal transduction regulated complex (ASTRC), such as polyA-binding protein, for degradation and this renders the mRNA susceptible to nucleases.

Literature References
PubMed ID Title Journal Year
11842200 Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs

Laroia, G, Sarkar, B, Schneider, RJ

Proc Natl Acad Sci U S A 2002
12136087 Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms

Laroia, G, Schneider, RJ

Nucleic Acids Res 2002
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Laroia, G, Cuesta, R, Brewer, G, Schneider, RJ

Science 1999
15257295 Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Lal, A, Mazan-Mamczarz, K, Kawai, T, Yang, X, Martindale, JL, Gorospe, M

EMBO J 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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