Reactome | AUF1:mRNA complex is degraded

AUF1:mRNA complex is degraded

Stable Identifier

R-HSA-450466

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitin-dependent proteolysis of AUF1 and nuclease-dependent destruction of AUF1-bound mRNA are coupled in an unknown way. It is possible that ubiquitinated AUF1 targets other members of the AUF1 and signal transduction regulated complex (ASTRC), such as polyA-binding protein, for degradation and this renders the mRNA susceptible to nucleases.

Literature References

PubMed ID	Title	Journal	Year
12136087	Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms Laroia, G, Schneider, RJ	Nucleic Acids Res	2002
11842200	Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs Laroia, G, Sarkar, B, Schneider, RJ	Proc Natl Acad Sci U S A	2002
10205060	Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Laroia, G, Cuesta, R, Brewer, G, Schneider, RJ	Science	1999
15257295	Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs Lal, A, Mazan-Mamczarz, K, Kawai, T, Yang, X, Martindale, JL, Gorospe, M	EMBO J	2004