AUF1:mRNA complex is destroyed

Stable Identifier
Reaction [omitted]
Homo sapiens
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Ubiquitin-dependent proteolysis of AUF1 and nuclease-dependent destruction of AUF1-bound mRNA are coupled in an unknown way. It is possible that ubiquitinated AUF1 targets other members of the AUF1 and signal transduction regulated complex (ASTRC), such as polyA-binding protein, for degradation and this renders the mRNA susceptible to nucleases.

Literature References
PubMed ID Title Journal Year
12136087 Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms

Schneider, RJ, Laroia, G

Nucleic Acids Res 2002
11842200 Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs

Schneider, RJ, Laroia, G, Sarkar, B

Proc Natl Acad Sci U S A 2002
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R

Science 1999
15257295 Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Gorospe, M, Yang, X, Mazan-Mamczarz, K, Lal, A, Kawai, T, Martindale, JL

EMBO J 2004
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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