Caspase-3 cleaves pro-interleukin-16

Stable Identifier
R-HSA-449073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase-3 cleaves pro-interleukin-16
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The mature and biologically active secreted interleukin-16 (IL16) is a 13-kDa carboxy terminal peptide derived from a larger intracellular precursor protein. Cleavage of IL16 from the propeptide is mediated by caspase-3. IL16 is a chemoattractant for a variety of cell types that express the cell surface antigen CD4.
Literature References
PubMed ID Title Journal Year
9422780 Processing and activation of pro-interleukin-16 by caspase-3

Zhang, Y, Center, DM, Wu, DM, Cruikshank, WW, Yuan, J, Andrews, DW, Kornfeld, H

J Biol Chem 1998
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Catalyst Activity

cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656)
Orthologous Events
Caspase-3 cleaves pro-interleukin-16 (Canis familiaris)
Caspase-3 cleaves pro-interleukin-16 (Mus musculus)
Caspase-3 cleaves pro-interleukin-16 (Rattus norvegicus)
Caspase-3 cleaves pro-interleukin-16 (Sus scrofa)
Caspase-3 cleaves pro-interleukin-16 (Xenopus tropicalis)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-27)
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