Formation of caspase-1 p10/p20 dimer

Stable Identifier
R-HSA-448673
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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Formation of caspase-1 p10/p20 dimer
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The p10 and p20 subunits first dimerize, then two dimers associate to give the active tetramer.

Literature References
PubMed ID Title Journal Year
8044845 Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

Walker, NP, Talanian, RV, Brady, KD, Dang, LC, Bump, NJ, Ferenz, CR, Franklin, S, Ghayur, T, Hackett, MC, Hammill, LD

Cell 1994
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Orthologous Events
Formation of caspase-1 p10/p20 dimer (Caenorhabditis elegans)
Formation of caspase-1 p10/p20 dimer (Danio rerio)
Formation of caspase-1 p10/p20 dimer (Drosophila melanogaster)
Formation of caspase-1 p10/p20 dimer (Gallus gallus)
Formation of caspase-1 p10/p20 dimer (Mus musculus)
Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)
Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-09-06)
Created
Jupe, S  (2009-11-25)