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IL21 [extracellular region]
Stable Identifier
R-HSA-448458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-21, IL21_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-21 signaling (Homo sapiens)
IL21 binds IL21R:JAK1 (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21 receptor JAK phosphorylation (Homo sapiens)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21 receptor STAT binding (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21 receptor STAT phosphorylation (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
IL21:IL21R:JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL21:IL21R:JAK1 [plasma membrane] (Homo sapiens)
IL21 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HBE4 IL21
Gene Names
IL21
Chain
signal peptide:1-24, chain:25-162
Reference Genes
BioGPS Gene:59067 IL21
COSMIC (genes):IL21 IL21
CTD Gene:59067 IL21
dbSNP Gene:59067 IL21
ENSEMBL:ENSG00000138684 IL21
HGNC:6005 IL21
KEGG Gene (Homo sapiens):59067 IL21
Monarch:59067 IL21
NCBI Gene:59067 IL21
OMIM:605384 IL21
UCSC:Q9HBE4 IL21
Reference Transcript
RefSeq:NM_001207006.2 IL21
RefSeq:NM_021803.3 IL21
Other Identifiers
0000870390
11753604_a_at
16979578
221271_at
2784289
2784290
2784291
2784292
2784293
2784294
2784295
2784296
2784297
2784298
2784299
59067
8102707
A_23_P167250
GO:0001819
GO:0002314
GO:0002376
GO:0002377
GO:0003674
GO:0005125
GO:0005126
GO:0005134
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0006464
GO:0006950
GO:0006955
GO:0007155
GO:0007165
GO:0007260
GO:0008150
GO:0008283
GO:0008284
GO:0021700
GO:0030154
GO:0030890
GO:0032729
GO:0032740
GO:0034105
GO:0038114
GO:0042102
GO:0042531
GO:0045954
GO:0048469
GO:0048856
GO:0050729
GO:0051607
GO:0061470
GO:0098586
ILMN_1772674
TC04001521.hg
g11141874_3p_at
Participant Of
input
IL21 binds IL21R:JAK1
hasComponent
IL21:IL21R:JAK1 [plasma membrane]
IL21:IL21R:p-Y-JAK1 [plasma membrane]
Inferred To
IL21 [extracellular region] (Canis familiaris)
IL21 [extracellular region] (Gallus gallus)
il21 [extracellular region] (Danio rerio)
il21 [extracellular region] (Xenopus tropicalis)
Il21 [extracellular region] (Mus musculus)
Il21 [extracellular region] (Rattus norvegicus)
Ghost homologue of IL21 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_068575.1
,
NP_001193935.1
OpenTargets
ENSG00000138684
GeneCards
Q9HBE4
HPA
ENSG00000138684-IL21
Ensembl
ENSP00000477555
,
ENSP00000497915
,
ENST00000611104
,
ENST00000648588
,
ENSG00000138684
PRO
Q9HBE4
PDB
2OQP
,
3TGX
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12797-6 ASPH
0.556
3
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