The Interleukin 1 receptor complex binds Tollip

Stable Identifier
R-HSA-446868
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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The Interleukin 1 receptor complex binds Tollip
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Toll-interacting protein (TOLLIP) binds to IRAK1 and IL-1RAP within the receptor complex. TOLLIP has the capacity to act as an ubiquitin-binding receptor for ubiquitinated IL1R1, linking IL1R to endosomal degradation.

Literature References
PubMed ID Title Journal Year
10854325 Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

Burns, K, Clatworthy, J, Martin, L, Martinon, F, Plumpton, C, Maschera, B, Lewis, A, Ray, KP, Tschopp, J, Volpe, F

Nat Cell Biol 2000
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Orthologous Events
The Interleukin 1 receptor complex binds Tollip (Bos taurus)
The Interleukin 1 receptor complex binds Tollip (Canis familiaris)
The Interleukin 1 receptor complex binds Tollip (Danio rerio)
The Interleukin 1 receptor complex binds Tollip (Gallus gallus)
The Interleukin 1 receptor complex binds Tollip (Mus musculus)
The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)
The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2009-11-18)