Toll-interacting protein (TOLLIP) binds to IRAK1 and IL-1RAP within the receptor complex. TOLLIP has the capacity to act as an ubiquitin-binding receptor for ubiquitinated IL1R1, linking IL1R to endosomal degradation.
Maschera, B, Volpe, F, Plumpton, C, Martinon, F, Ray, KP, Burns, K, Tschopp, J, Lewis, A, Martin, L, Clatworthy, J
© 2022 Reactome