IRAK4 phosphorylates IRAK1

Stable Identifier
R-HSA-446694
Type
Reaction
Species
Homo sapiens
Compartment
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MyD88 recruits unphosphorylated IRAK1 to the signaling complex. IRAK1 is then rapidly activated and autophosphorylates in a region that is outside the kinase domain (Cao et al. 1996). Several pieces of evidence suggest that IRAK4 triggers IRAK1 activation by phosphorylating its kinase activation loop, leading to IRAK1 autophosphorylation (Suzuki et al. 2002): in vitro kinase assays indicate that IRAK1 can be a direct substrate of IRAK4 (Li et al. 2002); IRAK1 phosphorylation by IRAK4 is independent of and precedes IRAK1 activation and autophosphorylation; IRAK1 autophosphorylation is partially inhibited in cells overexpressing a kinase-inactive IRAK4 protein (Li et al. 2002).

Literature References
PubMed ID Title Journal Year
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Wesche, H, Li, S, Fontana, EJ, Strelow, A

Proc Natl Acad Sci U S A 2002
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane]

Orthologous Events
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