Reactome | IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4

IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4

Stable Identifier

R-HSA-446648

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4

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MYD88 is a cytoplasmic adaptor protein that is recruited to the intracellular region of the IL1 receptor complex following IL1 stimulation. MYD88 binds to the complex of the two receptor chains and subsequently to IL-1 receptor-associated kinase 4 (IRAK4). This complex is the minimum required for signaling (Brikos et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
12538665	Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4 Brissoni, B, Janssens, S, Olivos, N, Burns, K, Beyaert, R, Tschopp, J	J Exp Med	2003
17507369	Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components Begum, S, Brikos, C, O'Neill, LA, Wait, R, Saklatvala, J	Mol Cell Proteomics	2007