IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4

Stable Identifier
R-HSA-446648
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MYD88 is a cytoplasmic adaptor protein that is recruited to the intracellular region of the IL1 receptor complex following IL1 stimulation. MYD88 binds to the complex of the two receptor chains and subsequently to IL-1 receptor-associated kinase 4 (IRAK4). This complex is the minimum required for signaling (Brikos et al. 2007).

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Orthologous Events
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