Addition of the first glucose to the N-glycan precursor by ALG6

Stable Identifier
R-HSA-446202
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The first glucose is added to the N-glycan precursor, mediated by ALG6. Defects in ALG6 are associated with CDG-Ic disorder (Imbach T et al, 1999; Sun L et al, 2005). The donor is a dolichol-phosphate-glucose (synthesized by ALG5).

Literature References
PubMed ID Title Journal Year
16007612 Clinical and molecular characterization of the first adult congenital disorder of glycosylation (CDG) type Ic patient

Sun, L, Eklund, EA, Van Hove, JL, Freeze, HH, Thomas, JA

Am J Med Genet A 2005
10359825 A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic

Imbach, T, Burda, P, Kuhnert, P, Wevers, RA, Aebi, M, Berger, EG, Hennet, T

Proc Natl Acad Sci U S A 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity of ALG6 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created