Reactome | Interaction between L1 and Ankyrins

Interaction between L1 and Ankyrins

Stable Identifier

R-HSA-445095

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Ankyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by three genes (ankyrin-G, -B and -R) of which ankyrin-G and -B are the major forms expressed in the developing nervous system. Ankyrins bind to the cytoplasmic domain of L1 CAMs and couple them and ion channel proteins, to the spectrin cytoskeleton. This binding enhances the homophilic adhesive activity of L1 and reduces its mobility within the plasma membrane. L1 interaction with ankyrin mediates branching and synaptogenesis of cortical inhibitory neurons.

Literature References

PubMed ID	Title	Journal	Year
18839070	The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM function Hortsch, M, Nagaraj, K, Godenschwege, TA	Cell Mol Biol Lett	2009
16904324	Phosphorylation of L1-type cell-adhesion molecules--ankyrins away! Nagaraj, K, Hortsch, M	Trends Biochem Sci	2006
20156840	Perisomatic GABAergic Innervation in Prefrontal Cortex Is Regulated by Ankyrin Interaction with the L1 Cell Adhesion Molecule Guan, H, Maness, PF	Cereb Cortex	2010
19356150	The intracellular interactions of the L1 family of cell adhesion molecules Herron, LR, Hill, M, Davey, F, Gunn-Moore, FJ	Biochem J	2009