CHL1 interacts with beta1 integrins

Stable Identifier
R-HSA-445088
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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CHL1 interacts with beta1 integrins
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CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis on the cell surface and promotes intracellular signaling, which stimulates cell migration on extracellular matrix proteins such as collagen-I. The integrin interaction motif, DGEA in the Ig6 domain of CHL1, is necessary to potentiate migration to collagen-I. CHL1 interacts with integrins to mediate radial migration of neural precursors in the development neocortex, and suppresses neuronal branching during migration.

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Input
Output
Participant Of
hasEvent
Inferred From
CHL1 interacts with beta1 integrins (Mus musculus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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