Relaxin receptor 2 binds relaxin 2 and INSL3

Stable Identifier
R-HSA-444879
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Relaxin receptor 2 (RXFP2 or LGR8) is activated by porcine relaxin, human relaxin-2 and insulin-like peptide-3 (INSL3). Relaxin affinity is lower than for Relaxin receptor 1, suggesting that this receptor functions as an INSL3 receptor.

Literature References
PubMed ID Title Journal Year
12506116 H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

Sudo, S, Kumagai, J, Nishi, S, Layfield, S, Ferraro, T, Bathgate, RA, Hsueh, AJ

J Biol Chem 2003
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Orthologous Events
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