Reactome | Relaxin receptor 2 binds relaxin 2 and INSL3

Relaxin receptor 2 binds relaxin 2 and INSL3

Stable Identifier

R-HSA-444879

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Relaxin receptors (Homo sapiens)
        
        Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)

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Relaxin receptor 2 binds relaxin 2 and INSL3

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Relaxin receptor 2 (RXFP2 or LGR8) is activated by porcine relaxin, human relaxin-2 and insulin-like peptide-3 (INSL3). Relaxin affinity is lower than for Relaxin receptor 1, suggesting that this receptor functions as an INSL3 receptor.

Literature References

PubMed ID	Title	Journal	Year
12506116	H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2 Kumagai, J, Bathgate, RA, Ferraro, T, Hsueh, AJ, Sudo, S, Layfield, S, Nishi, S	J Biol Chem	2003