Cho transports from the extracellular space to the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
CTL1-5 can mediate the uptake of choline
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Choline (Cho) transports from the extracellular space through the plasma membrane via the choline transporter-like proteins (SLC44A1-5 also known as CTL1-5) to the cytosol (Okuda & Haga 2000, Traiffort et al. 2005, O'Regan et al. 2000).

CTL1 is broadly expressed on leukocytes and endothelial cells (Wille et al. 2001). CTL2 is highly expressed in human inner ear and is the target of antibody-induced hearing loss (Nair et al. 2004).
Literature References
PubMed ID Title Journal Year
11068039 Functional characterization of the human high-affinity choline transporter

Haga, T, Okuda, T

FEBS Lett 2000
11698453 Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells

Wille, S, Knapp, W, Prieschl, EE, Staffler, G, Stockinger, H, Stockl, J, Szekeres, A, Majdic, O, Prager, E, Burtscher, H, Kunthalert, D, Baumruker, T, Zlabinger, GJ

J Immunol 2001
15715662 Molecular characterization of the family of choline transporter-like proteins and their splice variants

O'Regan, S, Meunier, FM, Ruat, M, Traiffort, E

J Neurochem 2005
10677542 An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins

Compaore, D, Cha, N, O'Regan, S, Meunier, FM, Ruat, M, Traiffort, E

Proc Natl Acad Sci U S A 2000
14973250 Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss

Lansford, CD, Lomax, MI, Gong, TW, Carey, TE, Kozma, KE, Raphael, Y, El-Kashlan, HK, Kommareddi, PK, Berryhill, WE, Satar, B, Ueda, Y, Nair, TS, Arts, HA, Hoefling, NL, Telian, SA

J Neurosci 2004
Catalyst Activity

choline transmembrane transporter activity of CTL1-5 [plasma membrane]

Orthologous Events
Cross References
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