Reactome | SCN1A [plasma membrane]

SCN1A [plasma membrane]

Stable Identifier

R-HSA-443378

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel protein type 1 subunit alpha, SCN1A_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN1A [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35498 SCN1A

Gene Names

SCN1A, NAC1, SCN1

Chain

chain:1-2009

Reference Genes

BioGPS Gene:6323 SCN1A

COSMIC (genes):SCN1A SCN1A

CTD Gene:6323 SCN1A

dbSNP Gene:6323 SCN1A

ENSEMBL:ENSG00000144285 SCN1A

HGNC:10585 SCN1A

Monarch:6323 SCN1A

NCBI Gene:6323 SCN1A

OMIM:182389 SCN1A

UCSC:P35498 SCN1A

Reference Transcript

Other Identifiers

11729015_at

11729016_a_at

1555246_PM_a_at

1555246_a_at

16904625

210383_PM_at

210383_at

2513486

2513492

2585318

2585319

2585321

2585323

2585324

2585325

2585326

2585327

2585328

2585329

2585330

2585331

2585332

2585333

2585334

2585335

2585336

2585337

2585338

2585342

2585344

2585346

2585347

2585349

2585350

2585351

2585352

2585353

2585354

2585355

2585356

2585357

2585358

2585359

2585360

2585362

2585363

2585364

2585365

2585366

2585367

2585368

2585369

2585370

2585371

2585373

2585374

2585375

2585376

2585386

52514_at

6323

8056457

A_21_P0002680

A_23_P28224

A_33_P3263533

GE550238

GE559185

GO:0001518

GO:0005215

GO:0005216

GO:0005248

GO:0005261

GO:0005272

GO:0005654

GO:0005886

GO:0006811

GO:0006814

GO:0007628

GO:0008340

GO:0014704

GO:0016020

GO:0016604

GO:0019227

GO:0019228

GO:0021675

GO:0030001

GO:0030018

GO:0030315

GO:0030424

GO:0033268

GO:0034220

GO:0034702

GO:0034706

GO:0035725

GO:0042391

GO:0043025

GO:0043194

GO:0046873

GO:0048856

GO:0050877

GO:0050884

GO:0050966

GO:0051649

GO:0055085

GO:0086002

GO:0086010

GO:0098655

GO:0098662

GO:0099505

GO:0099508

HMNXSV003006787

HMNXSV003051786

HMNXSV003052775

Hs2.22654.2.S1_3p_s_at

ILMN_1741059

PH_hs_0001985

TC02002496.hg

TC02004673.hg

TC02004674.hg

g12642269_3p_at

p20949

p26753

p33870

p9390

Participates

as a candidate of

SCNAs [plasma membrane] (Homo sapiens)

Inferred To

SCN1A [plasma membrane] (Bos taurus)

Cross References

Guide to Pharmacology - Targets

578

OpenTargets

ENSG00000144285

ENSEMBL

ENST00000637988, ENST00000409050, ENSP00000386312, ENSP00000490780, ENSP00000364554, ENST00000674923, ENST00000375405, ENSP00000501589, ENSP00000490799, ENST00000635750, ENSP00000303540, ENST00000303395

ZINC - Substances

SCN1A_HUMAN

ZINC target

P35498

ZINC - Biogenic

SCN1A_HUMAN

PRO

P35498

GlyGen

P35498

PDB

7DTD

HPA

ENSG00000144285-SCN1A

Pharos - Targets

P35498

Orphanet

SCN1A

ZINC - Predictions - Purchasable

SCN1A_HUMAN

HMDB Protein

HMDBP09078