Reactome | SCN9A [plasma membrane]

SCN9A [plasma membrane]

Stable Identifier

R-HSA-443374

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Sodium channel protein type 9 subunit alpha, SCN9A_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - L1CAM interactions (Homo sapiens)
      - Interaction between L1 and Ankyrins (Homo sapiens)
        
        Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN9A [plasma membrane] (Homo sapiens)
        
        NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs:SCNBs [plasma membrane] (Homo sapiens)
        
        SCNAs [plasma membrane] (Homo sapiens)
        
        SCN9A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15858 SCN9A

Gene Names

SCN9A, NENA

Chain

chain:1-1988

Reference Genes

BioGPS Gene:6335 SCN9A

COSMIC (genes):SCN9A SCN9A

CTD Gene:6335 SCN9A

dbSNP Gene:6335 SCN9A

ENSEMBL:ENSG00000169432 SCN9A

ENSEMBL_homo_sapiens_GENE:ENSG00000169432.19 SCN9A

HGNC:10597 SCN9A

KEGG Gene (Homo sapiens):6335 SCN9A

Monarch:6335 SCN9A

NCBI Gene:6335 SCN9A

OMIM:603415 SCN9A

UCSC:Q15858 SCN9A

Reference Transcript

Other Identifiers

11730102_at

11730103_at

16904667

206950_PM_at

206950_at

229199_PM_at

229199_at

2513487

2584990

2585401

2585402

2585403

2585404

2585406

2585407

2585409

2585410

2585411

2585412

2585414

2585417

2585418

2585421

2585425

2585427

2585428

2585429

2585431

2585432

2585433

2585436

2585437

2585439

2585441

2585444

2585445

2585446

2585447

2585448

2585449

2585451

2585452

2585453

2585454

2585460

32947_at

57701_at

6335

8056491

A_23_P112726

A_24_P3005

A_24_P792124

GE474388

GE520515

GO:0001518

GO:0005215

GO:0005216

GO:0005248

GO:0005261

GO:0005272

GO:0005515

GO:0005886

GO:0005891

GO:0006811

GO:0006814

GO:0006954

GO:0007623

GO:0008331

GO:0009636

GO:0009791

GO:0016020

GO:0019233

GO:0030424

GO:0034220

GO:0034702

GO:0035725

GO:0042995

GO:0043005

GO:0048266

GO:0048856

GO:0050877

GO:0050965

GO:0050974

GO:0055085

GO:0098703

HMNXSV003010502

Hs.13132.0.A1_3p_at

ILMN_1672591

ILMN_2169692

PH_hs_0000313

TC02002499.hg

TC02004675.hg

TC02004676.hg

X82835_at

g4506812_3p_at

Participates

as a component of

SCN9A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)

as a candidate of

SCNAs [plasma membrane] (Homo sapiens)

Inferred To

SCN9A [plasma membrane] (Bos taurus)

Cross References

RefSeq

XP_011509919.1, NP_002968.1, XP_005246814.1, XP_011509918.1, XP_011509920.1

ZINC - World Drugs

SCN9A_HUMAN

Guide to Pharmacology - Targets

584

OpenTargets

ENSG00000169432

ZINC - FDA approved

SCN9A_HUMAN

ZINC - Substances

SCN9A_HUMAN

ZINC - Biogenic

SCN9A_HUMAN

ZINC target

Q15858

PRO

Q15858

PDB

7W9T, 8G1A, 7XMG, 6VXO, 8S9C, 6N4Q, 7W9P, 6J8G, 8I5G, 7XVE, 8I5B, 6N4R, 8J4F, 6NT3, 6W6O, 6J8H, 8F0Q, 7XM9, 6J8I, 7W9K, 7K48, 8F0P, 6NT4, 7XVF, 5EK0, 7W9M, 7XMF, 8F0S, 8I5Y, 8S9B, 8F0R, 6J8J, 8I5X, 7W9L

GeneCards

Q15858

HPA

ENSG00000169432-SCN9A

Ensembl

ENST00000409672, ENSP00000495601, ENST00000303354, ENSP00000386306, ENSP00000304748, ENST00000645907, ENSG00000169432, ENSP00000495983, ENST00000642356

Pharos - Targets

Q15858

ZINC - Predictions - Purchasable

SCN9A_HUMAN

Orphanet

15255

HMDB Protein

HMDBP09089