NOTCH1 PEST domain mutants bind HES5 promoter

Stable Identifier
R-HSA-4396401
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants bind HES5 promoter
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NICD1 PEST domain mutants coactivator complexes are expected to bind HES5 promoter in a similar manner to the wild-type NOTCH1 Coactivator Complex (Arnett et al. 2010).
Literature References
PubMed ID Title Journal Year
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

Arnett, KL, Hass, M, McArthur, DG, Ilagan, MXG, Aster, JC, Kopan, R, Blacklow, SC

Nat Struct Mol Biol 2010
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Output
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as an event of
Normal reaction
NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Cross References
Mondo
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2013-08-23)
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