PIAS3 SUMOylates PGR with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS3 SUMOylates PGR (Progesterone receptor, PR) at lysine-7, lysine-388, and lysine-531 with SUMO1 (Man et al. 2006, Daniel et al. 2007, Abdel-Hafiz et al. 2009). SUMOylation inhibits hormone-dependent transcription activation by PGR.

Literature References
PubMed ID Title Journal Year
17020914 PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus

Shen, BF, Li, HY, Zhang, PJ, He, K, Pan, X, Zhou, T, Liang, B, Li, AL, Yu, M, Man, JH, Zhao, J, Jin, BF, Gong, WL, Zhang, XM, Xia, Q

Nucleic Acids Res. 2006
19211567 Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation

Dudevoir, ML, Abdel-Hafiz, H, Horwitz, KB

J. Biol. Chem. 2009
17717077 Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells

Lange, CA, Faivre, EJ, Daniel, AR

Mol. Endocrinol. 2007
Catalyst Activity

SUMO transferase activity of PIAS3 [nucleoplasm]

Orthologous Events
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