Reactome | PIAS3 SUMOylates PGR with SUMO1

PIAS3 SUMOylates PGR with SUMO1

Stable Identifier

R-HSA-4341073

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS3 SUMOylates PGR (Progesterone receptor, PR) at lysine-7, lysine-388, and lysine-531 with SUMO1 (Man et al. 2006, Daniel et al. 2007, Abdel-Hafiz et al. 2009). SUMOylation inhibits hormone-dependent transcription activation by PGR.

Literature References

PubMed ID	Title	Journal	Year
17020914	PIAS3 induction of PRB sumoylation represses PRB transactivation by destabilizing its retention in the nucleus Man, JH, Li, HY, Zhang, PJ, Zhou, T, He, K, Pan, X, Liang, B, Li, AL, Zhao, J, Gong, WL, Jin, BF, Xia, Q, Yu, M, Shen, BF, Zhang, XM	Nucleic Acids Res.	2006
19211567	Mechanisms underlying the control of progesterone receptor transcriptional activity by SUMOylation Abdel-Hafiz, H, Dudevoir, ML, Horwitz, KB	J. Biol. Chem.	2009
17717077	Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells Daniel, AR, Faivre, EJ, Lange, CA	Mol. Endocrinol.	2007