Reactome | SOAT can transport taurolithocholate-3-sulphate

SOAT can transport taurolithocholate-3-sulphate

Stable Identifier

R-HSA-433089

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SOAT can transport taurolithocholate-3-sulphate

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The human SLC10A6 gene encodes a sodium-dependant organic anion transporter, SOAT. Highest expressions of the gene are in testis, placenta and pancreas. Unlike the other SLC10A gene products, SOAT shows no affinity for binding bile acids. However, SOAT is able to transport sulpho-conjugated bile acids such as taurolithocholate 3-sulphate (Geyer J et al, 2007). It can also transport the structurally similar sulphated steroids (not shown here), thus SOAT may play a role in delivery of these prohormones to testis, pancreas and placenta.

Literature References

PubMed ID	Title	Journal	Year
17491011	Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6) Geyer, J, Döring, B, Meerkamp, K, Ugele, B, Bakhiya, N, Fernandes, CF, Godoy, JR, Glatt, H, Petzinger, E	J Biol Chem	2007