SOAT can transport taurolithocholate-3-sulphate

Stable Identifier
R-HSA-433089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human SLC10A6 gene encodes a sodium-dependant organic anion transporter, SOAT. Highest expressions of the gene are in testis, placenta and pancreas. Unlike the other SLC10A gene products, SOAT shows no affinity for binding bile acids. However, SOAT is able to transport sulpho-conjugated bile acids such as taurolithocholate 3-sulphate (Geyer J et al, 2007). It can also transport the structurally similar sulphated steroids (not shown here), thus SOAT may play a role in delivery of these prohormones to testis, pancreas and placenta.

Literature References
PubMed ID Title Journal Year
17491011 Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6)

Geyer, J, Döring, B, Meerkamp, K, Ugele, B, Bakhiya, N, Fernandes, CF, Godoy, JR, Glatt, H, Petzinger, E

J Biol Chem 2007
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Catalyst Activity
Title
bile acid:sodium symporter activity of SLC10A6 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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