Reactome | NCK binds PAK

NCK binds PAK

Stable Identifier

R-HSA-430183

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NCK binds to PAK through its second SH3 domain. PAK interacts with NCK via the amino terminal SH3 binding domain. This interaction leads to the phosphorylation of NCK at multiple sites.

Literature References

PubMed ID	Title	Journal	Year
8798379	The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 Schlessinger, J, Galisteo, ML, Skolnik, EY, Chernoff, J, Su, YC	J Biol Chem	1996
8824201	Interaction of the Nck adapter protein with p21-activated kinase (PAK1) Knaus, UG, Wang, Y, Bokoch, GM, Quilliam, LA, Bohl, BP, Sells, MA	J Biol Chem	1996