Reactome | NCK binds PAK

NCK binds PAK

Stable Identifier

R-HSA-430183

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NCK binds to PAK through its second SH3 domain. PAK interacts with NCK via the amino terminal SH3 binding domain. This interaction leads to the phosphorylation of NCK at multiple sites.

Literature References

PubMed ID	Title	Journal	Year
8798379	The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 Galisteo, ML, Chernoff, J, Su, YC, Skolnik, EY, Schlessinger, J	J Biol Chem	1996
8824201	Interaction of the Nck adapter protein with p21-activated kinase (PAK1) Bokoch, GM, Wang, Y, Bohl, BP, Sells, MA, Quilliam, LA, Knaus, UG	J Biol Chem	1996