p-SLP-76 binds VAV

Stable Identifier
Reaction [binding]
Homo sapiens
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SLP-76 is a hematopoietic cell-specific adapter protein. Studies indicate that three phosphotyrosines in SLP-76 (Y113, Y128, and Y145) are required for interactions with the SH2 domains of Vav1 (and Nck and Itk). This interaction is essential for membrane recruitment of Vav1. Similarly, association of Vav3 with SLP-76 was found to be essential for membrane recruitment. Vav2 has been shown to interact with SLP-76 in resting Jurkat cells.

Literature References
PubMed ID Title Journal Year
11262396 Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte

Charvet, C, Tartare-Deckert, S, Monthouel, MN, Deckert, M, Altman, A, Bernard, A, Foucault, I, Van Obberghen, E

J Biol Chem 2001
15708849 Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76

Billadeau, DD, Charvet, C, Altman, A, Canonigo, AJ

J Biol Chem 2005
8673706 Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

Motto, DG, Weiss, A, Koretzky, GA, Wu, J

Immunity 1996
Orthologous Events
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