SYK activation by SRC

Stable Identifier
R-HSA-429441
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SYK activation by SRC
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SYK activation in integrin signalling is associated with increased tyrosine phosphorylation. SYK activation and phosphorylation of SYK targets can be blocked by SRC inhibitors or expression of dominant negative SRC mutants.
Literature References
PubMed ID Title Journal Year
7513017 Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

Kurosaki, T, Takata, M, Yamanashi, Y, Inazu, T, Taniguchi, T, Yamamoto, T, Yamamura, H

J Exp Med 1994
9351824 Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

Gao, J, Zoller, KE, Ginsberg, MH, Brugge, JS, Shattil, SJ

EMBO J 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane]

Physical Entity
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SYK activation by SRC (Bos taurus)
SYK activation by SRC (Caenorhabditis elegans)
SYK activation by SRC (Canis familiaris)
SYK activation by SRC (Danio rerio)
SYK activation by SRC (Gallus gallus)
SYK activation by SRC (Mus musculus)
SYK activation by SRC (Rattus norvegicus)
SYK activation by SRC (Sus scrofa)
SYK activation by SRC (Xenopus tropicalis)
Authored
Akkerman, JW  (2009-06-03)
Reviewed
Heemskerk, JW  (2010-09-01)
Created
Jupe, S  (2009-07-15)
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