SYK activation in integrin signalling is associated with increased tyrosine phosphorylation. SYK activation and phosphorylation of SYK targets can be blocked by SRC inhibitors or expression of dominant negative SRC mutants.
Yamamoto, T, Taniguchi, T, Yamanashi, Y, Takata, M, Inazu, T, Yamamura, H, Kurosaki, T
Brugge, JS, Ginsberg, MH, Zoller, KE, Gao, J, Shattil, SJ
protein tyrosine kinase activity of Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane]
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