Recruitment of Profilin by Ena/VASP proteins

Stable Identifier
R-HSA-428534
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Ena/VASP proteins (ENAH, EVL1 and VASP) enhance actin filament elongation via the recruitment of profilin:actin complexes to the tips of spreading lamellipodia. Profilin (PFN1 or PFN2) binds to the central proline rich domain of an Ena/VASP protein (Bashaw et al. 2000).

Literature References
PubMed ID Title Journal Year
10892742 Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Bashaw, GJ, Kidd, T, Murray, D, Pawson, T, Goodman, CS

Cell 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed