Reactome | SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol

SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol

Stable Identifier

R-HSA-427555

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol

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The SLC26A1 and 2 genes encode proteins that facilitate sulfate (SO4(2-)) uptake into cells. The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting one of several possible anions like hydrogen carbonate, oxalate, chloride or nitrate (reviewed in Mount & Romer, 2004; Alper & Sharma 2013). SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Bissig et al., 1994; Regeer et al., 2003) and is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body. SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka et al. 1994). This transporter provides sulfate for sulfation of glycosaminoglycan chains in proteoglycans needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias (reviewed in Rossi & Superti-Furga, 2001).

Literature References

PubMed ID	Title	Journal	Year
11241838	Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene (SLC26A2): 22 novel mutations, mutation review, associated skeletal phenotypes, and diagnostic relevance Rossi, A, Superti-Furga, A	Hum Mutat	2001
12759755	The SLC26 gene family of multifunctional anion exchangers Mount, DB, Romero, MF	Pflugers Arch	2004
7923357	The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping de la Chapelle, A, Mahtani, MM, Clines, G, Reeve-Daly, MP, Daly, M, Hamilton, BA, Kusumi, K, Trivedi, B, Weaver, A	Cell	1994
8300633	Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes Bissig, M, Hagenbuch, B, Stieger, B, Koller, T, Meier, PJ	J Biol Chem	1994
23506885	The SLC26 gene family of anion transporters and channels Alper, SL, Sharma, AK	Mol. Aspects Med.	2013
12713736	Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1) Regeer, RR, Lee, A, Markovich, D	DNA Cell Biol	2003