CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9

Stable Identifier
R-HSA-427383
Type
Reaction [binding]
Species
Homo sapiens
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As inferred from mouse, CBX3 (Heterochromatic Protein 1gamma, HP1gamma) binds histone H3 dimethylated at lysine-9 (H3K9me2). In other regions of the genome, CBX3 can be associated with repression of transcription, however dimethylated H3 lysine-9 and CBX3 in the transcribed region of the rRNA gene are associated with enhanced expression. CBX3 bound to gene bodies can facilitate cotranscriptional processing of RNA (Smallwood et al. 2012).

Literature References
PubMed ID Title Journal Year
22684280 CBX3 regulates efficient RNA processing genome-wide

Smallwood, A, Hon, GC, Jin, F, Henry, RE, Espinosa, JM, Ren, B

Genome Res. 2012
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