Transcription of intergenic spacer of the rRNA gene

Stable Identifier
R-HSA-427366
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Transcription of intergenic spacer of the rRNA gene
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As inferred from mouse cell models, intergenic spacer regions (IGS) located between rRNA transcription units contain upstream promoters and are transcribed by RNA Polymerase I. The IGS transcripts originate approximately 2 Kb upstream of the start of rRNA transcription and proceed though the main promoter of the rRNA gene.

Literature References
PubMed ID Title Journal Year
19838300 An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells

Alvord, WG, Gu, YD, Hwang, CJ, Anderson, LM, Kasprzak, W, Fields, JR, Shiao, YH, Shapiro, BA, Quiñones, O, Leighty, RM, Lupascu, ST

PLoS One 2009
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Output
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as an event of
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase I promoter escape complex [nucleoplasm]

Physical Entity
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
Activity
DNA-directed 5'-3' RNA polymerase activity (GO:0003899)
Inferred From
Transcription of intergenic spacer of the rRNA gene (Mus musculus)
Authored
May, B  (2009-06-19)
Reviewed
Shiao, YH  (2014-02-18)
Created
May, B  (2009-06-20)
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