Reactome | SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

Stable Identifier

R-HSA-426086

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Na+, K+/2Cl- cotransport

ReviewStatus

5/5

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SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

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Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.

Literature References

PubMed ID	Title	Journal	Year
7629105	Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon Haas, M, Ward, D, Lytle, CY, Xu, JC, Forbush B, 3rd, Payne, JA	J Biol Chem	1995
8640224	Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2 Lifton, RP, Hamdan, JM, DiPietro, A, Simon, DB, Karet, FE, Sanjad, SA	Nat Genet	1996