Reactome | DAGLA [plasma membrane]

DAGLA [plasma membrane]

Stable Identifier

R-HSA-426022

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Diacylglycerol lipase alpha, Sn1-specific diacylglycerol lipase alpha, DGLA_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Effects of PIP2 hydrolysis (Homo sapiens)
        
        Arachidonate production from DAG (Homo sapiens)
        
        DAG is metabolized by DAGL to 2-AG (Homo sapiens)
        
        Diacylglycerol lipase [plasma membrane] (Homo sapiens)
        
        DAGLA [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y4D2 DAGLA

Gene Names

DAGLA, C11orf11, KIAA0659, NSDDR

Chain

chain:1-1042

Reference Genes

BioGPS Gene:747 DAGLA

COSMIC (genes):DAGLA DAGLA

CTD Gene:747 DAGLA

dbSNP Gene:747 DAGLA

ENSEMBL:ENSG00000134780.10 DAGLA

HGNC:1165 DAGLA

KEGG Gene (Homo sapiens):747 DAGLA

Monarch:747 DAGLA

NCBI Gene:747 DAGLA

OMIM:614015 DAGLA

UCSC:Q9Y4D2 DAGLA

Reference Transcript

RefSeq:NM_006133.2 DAGLA

Other Identifiers

0000940102

11726435_at

16725670

214128_PM_at

214128_at

3333117

3333118

3333134

3333135

3333137

3333138

3333139

3333142

3333143

3333146

3333148

3333149

3333150

3333151

3333152

3333153

3333154

3333155

3333156

3333158

3333159

3333160

3333161

3333162

3333163

3333164

35511_at

747

7940508

A_24_P115967

GE53369

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0006629

GO:0006954

GO:0007216

GO:0007405

GO:0008150

GO:0016020

GO:0016021

GO:0016042

GO:0016787

GO:0019369

GO:0022008

GO:0023052

GO:0030054

GO:0030154

GO:0031410

GO:0031901

GO:0032590

GO:0032591

GO:0042136

GO:0042995

GO:0043167

GO:0043196

GO:0043226

GO:0045202

GO:0045211

GO:0046340

GO:0046872

GO:0047372

GO:0048856

GO:0071926

GO:0098839

GO:0098921

GO:0099055

GO:0150077

HMNXSV003019758

Hs.124275.0.S1_3p_at

ILMN_1683682

PH_hs_0023189

TC11000538.hg

Participates

as a member of

Diacylglycerol lipase [plasma membrane] (Homo sapiens)

Inferred To

inaE [plasma membrane] (Drosophila melanogaster)

Dagla [plasma membrane] (Mus musculus)

Dagla [plasma membrane] (Rattus norvegicus)

Homologues of DAGLA [plasma membrane] (Danio rerio)

DAGLA [plasma membrane] (Bos taurus)

DAGLA [plasma membrane] (Canis familiaris)

DAGLA [plasma membrane] (Danio rerio)

DAGLA [plasma membrane] (Dictyostelium discoideum)

DAGLA [plasma membrane] (Gallus gallus)

DAGLA [plasma membrane] (Sus scrofa)

dagla [plasma membrane] (Danio rerio)

dagla [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_006124.1

ZINC - World Drugs

DGLA_HUMAN

Guide to Pharmacology - Targets

1396

OpenTargets

ENSG00000134780

ZINC - FDA approved

DGLA_HUMAN

ZINC - Substances

DGLA_HUMAN

ZINC target

Q9Y4D2

PRO

Q9Y4D2

IntEnz

3.1.1.116

GeneCards

Q9Y4D2

HPA

ENSG00000134780-DAGLA

Ensembl

ENSG00000134780, ENST00000257215, ENSP00000257215

Pharos - Targets

Q9Y4D2

ZINC - Predictions - Purchasable

DGLA_HUMAN

Orphanet

28456

HMDB Protein

HMDBP07282