Reactome | Ghrelin O-acyltransferase octanoylates Proghrelin

Ghrelin O-acyltransferase octanoylates Proghrelin

Stable Identifier

R-HSA-422104

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

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Ghrelin O-acyltransferase octanoylates Proghrelin

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Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification.

Literature References

PubMed ID	Title	Journal	Year
18396350	Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle Soares, JB, Leite-Moreira, AF	Peptides	2008
19280057	Ghrelin fluctuation, what determines its production? Yin, X, Li, Y, Xu, G, An, W, Zhang, W	Acta Biochim Biophys Sin (Shanghai)	2009
12414809	Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing Hosoda, H, Kojima, M, Mizushima, T, Shimizu, S, Kangawa, K	J Biol Chem	2003
19628676	Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid Takahashi, T, Ida, T, Sato, T, Nakashima, Y, Nakamura, Y, Tsuji, A, Kojima, M	J Biochem	2009
18443287	Ghrelin octanoylation mediated by an orphan lipid transferase Gutierrez, JA, Solenberg, PJ, Perkins, DR, Willency, JA, Knierman, MD, Jin, Z, Witcher, DR, Luo, S, Onyia, JE, Hale, JE	Proc Natl Acad Sci U S A	2008