Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification.
Yin, X, Li, Y, Zhang, W, An, W, Xu, G
Soares, JB, Leite-Moreira, AF
Kangawa, K, Hosoda, H, Mizushima, T, Shimizu, S, Kojima, M
Nakamura, Y, Ida, T, Tsuji, A, Sato, T, Takahashi, T, Nakashima, Y, Kojima, M
Knierman, MD, Luo, S, Hale, JE, Jin, Z, Onyia, JE, Witcher, DR, Willency, JA, Perkins, DR, Solenberg, PJ, Gutierrez, JA
O-acyltransferase activity of MBOAT4 [endoplasmic reticulum membrane]
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