Ghrelin O-acyltransferase octanoylates Proghrelin

Stable Identifier
Reaction [transition]
Homo sapiens
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Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification.

Literature References
PubMed ID Title Journal Year
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Zhang, W, An, W, Xu, G

Acta Biochim Biophys Sin (Shanghai) 2009
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
12414809 Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing

Kangawa, K, Hosoda, H, Mizushima, T, Shimizu, S, Kojima, M

J Biol Chem 2003
19628676 Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid

Nakamura, Y, Ida, T, Tsuji, A, Sato, T, Takahashi, T, Nakashima, Y, Kojima, M

J Biochem 2009
18443287 Ghrelin octanoylation mediated by an orphan lipid transferase

Knierman, MD, Luo, S, Hale, JE, Jin, Z, Onyia, JE, Witcher, DR, Willency, JA, Perkins, DR, Solenberg, PJ, Gutierrez, JA

Proc Natl Acad Sci U S A 2008
Catalyst Activity

O-acyltransferase activity of MBOAT4 [endoplasmic reticulum membrane]

Orthologous Events
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