Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification.
Soares, JB, Leite-Moreira, AF
Yin, X, Li, Y, Xu, G, An, W, Zhang, W
Hosoda, H, Kojima, M, Mizushima, T, Shimizu, S, Kangawa, K
Takahashi, T, Ida, T, Sato, T, Nakashima, Y, Nakamura, Y, Tsuji, A, Kojima, M
Gutierrez, JA, Solenberg, PJ, Perkins, DR, Willency, JA, Knierman, MD, Jin, Z, Witcher, DR, Luo, S, Onyia, JE, Hale, JE
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