Reactome | Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture

Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture

Stable Identifier

R-HSA-421833

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the Golgi-associated vesicle membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.

Literature References

PubMed ID	Title	Journal	Year
11694590	GGAs: roles of the different domains and comparison with AP-1 and clathrin Hirst, J, Lindsay, MR, Robinson, MS	Mol Biol Cell	2001
11994746	Regulated transport of the glucose transporter GLUT4. Bryant, NJ, Govers, R, James, DE	Nat Rev Mol Cell Biol	2002
17116749	Comparative proteomics of clathrin-coated vesicles Borner, GH, Harbour, M, Hester, S, Lilley, KS, Robinson, MS	J Cell Biol	2006