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GRM8 [plasma membrane]
Stable Identifier
R-HSA-420567
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Metabotropic glutamate receptor 8, GRM8_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
Metabotropic glutamate receptors bind glutamate (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
GRM8 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00222 GRM8
Gene Names
GRM8, GPRC1H, MGLUR8
Chain
signal peptide:1-33, chain:34-908
Reference Genes
BioGPS Gene:2918 GRM8
COSMIC (genes):GRM8 GRM8
CTD Gene:2918 GRM8
dbSNP Gene:2918 GRM8
ENSEMBL:ENSG00000179603 GRM8
HGNC:4600 GRM8
KEGG Gene (Homo sapiens):2918 GRM8
Monarch:2918 GRM8
NCBI Gene:2918 GRM8
OMIM:601116 GRM8
UCSC:O00222 GRM8
Reference Transcript
RefSeq:XM_017012074.1 GRM8
RefSeq:NM_001127323.1 GRM8
RefSeq:XM_011516091.1 GRM8
RefSeq:XM_011516092.2 GRM8
RefSeq:NM_000845.2 GRM8
RefSeq:XM_006715938.3 GRM8
Other Identifiers
0005080008
11729743_a_at
11755833_a_at
17062542
216255_s_at
216992_s_at
2918
3005129
3005130
3005131
3071069
3071070
3071071
3071072
3071075
3071076
3071084
3071085
3071086
3071096
3071101
3071110
3071123
3071124
3071125
3071139
3071170
3071171
3071172
3071173
3071178
3071179
3071180
3071181
3071182
3071183
34007_at
8142718
A_32_P8221
A_33_P3241135
GE80958
GO:0001642
GO:0003674
GO:0004930
GO:0005575
GO:0005886
GO:0005887
GO:0007165
GO:0007186
GO:0007193
GO:0007196
GO:0007216
GO:0007267
GO:0007601
GO:0008066
GO:0008150
GO:0016020
GO:0016021
GO:0050877
GO:0050896
GO:0051966
Hs.86204.2.S1_3p_a_at
ILMN_1729212
PH_hs_0026981
TC07003151.hg
U92459_at
Participant Of
hasMember
GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane]
Inferred To
grm8a [plasma membrane] (Danio rerio)
mgl-3 [plasma membrane] (Caenorhabditis elegans)
GRM8 [plasma membrane] (Bos taurus)
GRM8 [plasma membrane] (Canis familiaris)
GRM8 [plasma membrane] (Gallus gallus)
GRM8 [plasma membrane] (Sus scrofa)
Grm8 [plasma membrane] (Mus musculus)
Grm8 [plasma membrane] (Rattus norvegicus)
Cross References
RefSeq
XP_011514394.1
,
XP_016867563.1
,
NP_000836.2
,
NP_001120795.1
,
XP_011514393.1
,
XP_006716001.1
ZINC - World Drugs
GRM8_HUMAN
OpenTargets
ENSG00000179603
ZINC - FDA approved
GRM8_HUMAN
ZINC - Substances
GRM8_HUMAN
ZINC target
O00222
ZINC - Biogenic
GRM8_HUMAN
PRO
O00222
PDB
6BT5
,
6BSZ
,
6E5V
ZINC - Metabolites
GRM8_HUMAN
HPA
ENSG00000179603-GRM8
GeneCards
O00222
Ensembl
ENST00000472701
,
ENSP00000345747
,
ENSP00000419832
,
ENST00000341617
,
ENSP00000351142
,
ENST00000358373
,
ENSG00000179603
,
ENSP00000344173
,
ENST00000339582
ZINC - Predictions - Purchasable
GRM8_HUMAN
Orphanet
24577
HMDB Protein
HMDBP10860
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