Reactome | GRM8 [plasma membrane]

GRM8 [plasma membrane]

Stable Identifier

R-HSA-420567

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Metabotropic glutamate receptor 8, GRM8_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Group II and III metabotropic gutamate receptors:Glu [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - Metabotropic glutamate receptors bind glutamate (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)
        
        GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
        
        GRM1-8 [plasma membrane] (Homo sapiens)
        
        GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)
        
        GRM8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00222 GRM8

Gene Names

GRM8, GPRC1H, MGLUR8

Chain

signal peptide:1-33, chain:34-908

Reference Genes

BioGPS Gene:2918 GRM8

COSMIC (genes):GRM8 GRM8

CTD Gene:2918 GRM8

dbSNP Gene:2918 GRM8

ENSEMBL:ENSG00000179603 GRM8

HGNC:4600 GRM8

KEGG:hsa:2918 GRM8

Monarch:2918 GRM8

NCBI Gene:2918 GRM8

OMIM:601116 GRM8

UCSC:O00222 GRM8

Reference Transcript

Other Identifiers

11729743_a_at

11755833_a_at

17062542

216255_PM_s_at

216255_s_at

216256_PM_at

216256_at

216992_PM_s_at

216992_s_at

2918

3005129

3005130

3005131

3071069

3071070

3071071

3071072

3071075

3071076

3071077

3071084

3071085

3071086

3071096

3071101

3071109

3071110

3071123

3071124

3071125

3071132

3071133

3071134

3071137

3071139

3071140

3071141

3071168

3071169

3071170

3071171

3071172

3071173

3071175

3071176

3071178

3071179

3071180

3071181

3071182

3071183

3071206

3071207

3071208

3071210

34007_at

65065_at

8142718

AC000099_at

A_32_P8221

A_33_P3241135

GE537782

GE80958

GO:0001642

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0007193

GO:0007196

GO:0007216

GO:0007601

GO:0008066

GO:0016020

GO:0050877

GO:0051966

GO:0060089

HMNXSV003012400

HMNXSV003017090

Hs.86204.1.S1_3p_at

Hs.86204.2.S1_3p_a_at

ILMN_1729212

PH_hs_0026981

TC07003151.hg

U92459_at

p15093

Participates

as a member of

GRM2,GRM3,GRM4,GRM6,GRM7,GRM8 [plasma membrane] (Homo sapiens)

Inferred To

grm8a [plasma membrane] (Danio rerio)

mgl-3 [plasma membrane] (Caenorhabditis elegans)

GRM8 [plasma membrane] (Bos taurus)

GRM8 [plasma membrane] (Canis familiaris)

GRM8 [plasma membrane] (Gallus gallus)

GRM8 [plasma membrane] (Mus musculus)

GRM8 [plasma membrane] (Rattus norvegicus)

GRM8 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001120795.1, XP_011514394.1, XP_011514393.1, XP_016867563.1, XP_006716001.1, NP_000836.2

ZINC - World Drugs

GRM8_HUMAN

Guide to Pharmacology - Targets

296

OpenTargets

ENSG00000179603

ENSEMBL

ENST00000706916, ENSP00000344173, ENSP00000419832, ENSP00000345747, ENSP00000351142, ENST00000706917, ENST00000341617, ENST00000472701, ENST00000358373, ENST00000339582, ENSP00000516624, ENSP00000516625

ZINC - FDA approved

GRM8_HUMAN

ZINC - Substances

GRM8_HUMAN

ZINC - Biogenic

GRM8_HUMAN

ZINC target

O00222

PRO

O00222

GlyGen

O00222

PDB

6E5V, 6BSZ, 6BT5

ZINC - Metabolites

GRM8_HUMAN

HPA

ENSG00000179603-GRM8

Pharos - Targets

O00222

ZINC - Predictions - Purchasable

GRM8_HUMAN

HMDB Protein

HMDBP10860