Reactome | Parathyroid hormone receptor can bind parathyroid hormone

Parathyroid hormone receptor can bind parathyroid hormone

Stable Identifier

R-HSA-420489

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Parathyroid hormone receptor can bind parathyroid hormone

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroid hormone-related protein (PTHrP) (Suva LJ et al, 1987) and tuberoinfundibular peptide of thirty-nine residues (TIP39) (Hansen IA et al, 2002; Della Penna K et al, 2003) are endogenous ligands for the parathyroid hormone 1 and 2 receptors. These peptide hormones play a key role in controlling blood Ca(2+) concentration and endochondral bone formation. PTH1 is the classical PTH receptor 1 (Schipani E et al, 1993; Schneider H et al, 1993) and is expressed in high levels in bone and kidney. It regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. PTH receptor 2 (Usdin TB et al, 1995) is most abundant in brain and testes and potently activated by PTH. The activity of these receptors is mediated by G proteins which activate adenylyl cyclase (Schneider H et al, 1994; Offermanns S et al, 1996; Behar V et al, 1996).

Literature References

PubMed ID	Title	Journal	Year
8397094	Cloning and functional expression of a human parathyroid hormone receptor Feyen, JH, Schneider, H, Movva, NR, Seuwen, K	Eur J Pharmacol	1993
8732687	G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells Offermanns, S, Simon, MI, Segre, GV, Iida-Klein, A	Mol Endocrinol	1996
6950381	Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone Kronenberg, HM, Rich, A, Potts JT, Jr, Hendy, GN	Proc Natl Acad Sci U S A	1981
3616618	A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression Winslow, GA, Chen, EY, Rodriguez, H, Suva, LJ, Kemp, BE, Rodda, CP, Moseley, JM, Wettenhall, RE, Hammonds, RG, Diefenbach-Jagger, H	Science	1987
12559132	Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor Sun, H, Wang, H, Kinose, F, Koblan, KS, Della Penna, K	Neuropharmacology	2003
12098667	Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family Allolio, B, Hansen, IA, Jakob, O, Arzberger, T, Wortmann, S, Blind, E	J Endocrinol	2002
8386612	Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor Karga, H, Abou-Samra, AB, Karaplis, AC, Schipani, E, Segre, GV, Jüppner, H, Kronenberg, HM, Potts JT, Jr	Endocrinology	1993
8770894	The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor Nakamoto, C, Greenberg, Z, Rosenblatt, M, Usdin, TB, Suva, LJ, Stueckle, SM, Chorev, M, Pines, M, Bisello, A, Bessalle, R, Behar, V	Endocrinology	1996
7797535	Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor Usdin, TB, Gruber, C, Bonner, TI	J Biol Chem	1995
8082781	A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins Feyen, JH, Schneider, H, Seuwen, K	FEBS Lett	1994