Parathyroid hormone receptor can bind parathyroid hormone

Stable Identifier
R-HSA-420489
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Parathyroid hormone (PTH) (Hendy GN et al, 1981), parathyroid hormone-related protein (PTHrP) (Suva LJ et al, 1987) and tuberoinfundibular peptide of thirty-nine residues (TIP39) (Hansen IA et al, 2002; Della Penna K et al, 2003) are endogenous ligands for the parathyroid hormone 1 and 2 receptors. These peptide hormones play a key role in controlling blood Ca(2+) concentration and endochondral bone formation. PTH1 is the classical PTH receptor 1 (Schipani E et al, 1993; Schneider H et al, 1993) and is expressed in high levels in bone and kidney. It regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. PTH receptor 2 (Usdin TB et al, 1995) is most abundant in brain and testes and potently activated by PTH. The activity of these receptors is mediated by G proteins which activate adenylyl cyclase (Schneider H et al, 1994; Offermanns S et al, 1996; Behar V et al, 1996).

Literature References
PubMed ID Title Journal Year
8732687 G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells

Offermanns, S, Iida-Klein, A, Segre, GV, Simon, MI

Mol Endocrinol 1996
8397094 Cloning and functional expression of a human parathyroid hormone receptor

Schneider, H, Feyen, JH, Seuwen, K, Movva, NR

Eur J Pharmacol 1993
6950381 Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone

Hendy, GN, Kronenberg, HM, Potts JT, Jr, Rich, A

Proc Natl Acad Sci U S A 1981
3616618 A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression

Suva, LJ, Winslow, GA, Wettenhall, RE, Hammonds, RG, Moseley, JM, Diefenbach-Jagger, H, Rodda, CP, Kemp, BE, Rodriguez, H, Chen, EY

Science 1987
12559132 Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor

Della Penna, K, Kinose, F, Sun, H, Koblan, KS, Wang, H

Neuropharmacology 2003
12098667 Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family

Hansen, IA, Jakob, O, Wortmann, S, Arzberger, T, Allolio, B, Blind, E

J Endocrinol 2002
8386612 Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor

Schipani, E, Karga, H, Karaplis, AC, Potts JT, Jr, Kronenberg, HM, Segre, GV, Abou-Samra, AB, J├╝ppner, H

Endocrinology 1993
8770894 The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor

Behar, V, Pines, M, Nakamoto, C, Greenberg, Z, Bisello, A, Stueckle, SM, Bessalle, R, Usdin, TB, Chorev, M, Rosenblatt, M, Suva, LJ

Endocrinology 1996
7797535 Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor

Usdin, TB, Gruber, C, Bonner, TI

J Biol Chem 1995
8082781 A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins

Schneider, H, Feyen, JH, Seuwen, K

FEBS Lett 1994
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