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PTH2R [plasma membrane]
Stable Identifier
R-HSA-420476
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Parathyroid hormone 2 receptor, PTH2R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49190 PTH2R
Gene Names
PTH2R, PTHR2
Chain
signal peptide:1-24, chain:25-550
Reference Genes
BioGPS Gene:5746 PTH2R
COSMIC - genes:PTH2R PTH2R
CTD Gene:5746 PTH2R
dbSNP Gene:5746 PTH2R
ENSEMBL:ENSG00000144407 PTH2R
HGNC:9609 PTH2R
KEGG:hsa:5746 PTH2R
Monarch:5746 PTH2R
NCBI Gene:5746 PTH2R
OMIM:601469 PTH2R
UCSC:P49190 PTH2R
Reference Transcript
RefSeq:NM_005048.4 PTH2R
RefSeq:NM_001309516.1 PTH2R
Other Identifiers
11732693_a_at
11732694_at
11748069_a_at
16890176
206772_PM_at
206772_at
2525355
2525356
2525357
2525358
2525362
2525363
2525364
2525365
2525366
2525367
2525368
2525369
2525376
2525377
2525378
2525379
2525380
2525381
2525394
2525399
2525400
2525404
2525413
2525414
2525415
2525416
2525417
2525418
2525445
36388_at
5746
8047910
83848_g_at
83850_at
A_14_P130626
A_23_P380901
A_24_P457628
GE61526
GO:0004888
GO:0004930
GO:0004991
GO:0005515
GO:0005886
GO:0007165
GO:0007166
GO:0007186
GO:0007188
GO:0008528
GO:0016020
GO:0017046
GO:0120162
HMNXSV003023754
HMNXSV003056736
HMNXSV003057492
HMNXSV003057947
ILMN_1729075
PH_hs_0009712
TC02001236.hg
U25128_at
g4826953_3p_at
Participates
as a member of
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
Inferred To
pth2r [plasma membrane]
(Xenopus tropicalis)
Pth2r [plasma membrane]
(Mus musculus)
Pth2r [plasma membrane]
(Rattus norvegicus)
PTH2R [plasma membrane]
(Bos taurus)
PTH2R [plasma membrane]
(Canis familiaris)
PTH2R [plasma membrane]
(Sus scrofa)
pth2ra [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001296445.1
,
NP_005039.1
Guide to Pharmacology - Targets
332
ENSEMBL
ENSP00000272847
,
ENSG00000144407
,
ENST00000272847
OpenTargets
ENSG00000144407
GeneCards
PTH2R
HPA
ENSG00000144407-PTH2R
PRO
P49190
Pharos - Targets
P49190
GlyGen
P49190
PDB
7F16
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63172 DYNLT1
4
DYNLT1 [ficolin-1-rich granule lumen]
(R-HSA-6801487)
DYNLT1 [extracellular region]
(R-HSA-6806509)
DYNLT1 [secretory granule lumen]
(R-HSA-6801497)
DYNLT1 [cytosol]
(R-HSA-6801602)
0.556
3
UniProt:Q6JQN1 ACAD10
1
ACAD10 [mitochondrial matrix]
(R-HSA-5695955)
0.527
2
UniProt:P13591 NCAM1
2
NCAM1 [plasma membrane]
(R-HSA-190987)
6xN-linked glycan core-NCAM1 [Golgi membrane]
(R-HSA-422430)
0.527
2
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