Reactome | Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Stable Identifier

R-HSA-419981

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PAR-3 exists in a ternary complex with aPKC and PAR-6 to form the PAR-aPKC complex (Macara, 2004; Suzuki and Ohno, 2006). This complex is critically involved in the development of Tight Junctions (TJs) from primordial spot-like Adherens Junctions (AJs) (Suzuki et al., 2002). PAR-3 directly interacts with Junctional Adhesion Molecules (JAM)-A, -B, and -C (Ebnet et al., 2001; Ebnet et al., 2004).The interaction with JAM-A might anchor the PAR-aPKC complex to TJs but might also be necessary to recruit the PAR-aPKC complex to primordial spot-like AJs where it becomes activated in response to cell-cell adhesion (reviewed in (Ebnet et al., 2008). The PAR-aPKC complex might also be physically linked to the second polarity protein complex at TJs, the CRB3-Pals1-PATJ complex through a direct interaction between PAR-6 and Pals1 (Hurd et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12953056	The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity Ebnet, K, Aurrand-Lions, M, Kuhn, A, Kiefer, F, Butz, S, Zander, K, Meyer zu Brickwedde, MK, Suzuki, A, Imhof, BA, Vestweber, D	J Cell Sci	2003
11447115	The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM) Ebnet, K, Suzuki, A, Horikoshi, Y, Hirose, T, Meyer zu Brickwedde, MK, Ohno, S, Vestweber, D	EMBO J	2001