Reactome | Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Stable Identifier

R-HSA-419981

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

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PAR-3 exists in a ternary complex with aPKC and PAR-6 to form the PAR-aPKC complex (Macara, 2004; Suzuki and Ohno, 2006). This complex is critically involved in the development of Tight Junctions (TJs) from primordial spot-like Adherens Junctions (AJs) (Suzuki et al., 2002). PAR-3 directly interacts with Junctional Adhesion Molecules (JAM)-A, -B, and -C (Ebnet et al., 2001; Ebnet et al., 2004).The interaction with JAM-A might anchor the PAR-aPKC complex to TJs but might also be necessary to recruit the PAR-aPKC complex to primordial spot-like AJs where it becomes activated in response to cell-cell adhesion (reviewed in (Ebnet et al., 2008). The PAR-aPKC complex might also be physically linked to the second polarity protein complex at TJs, the CRB3-Pals1-PATJ complex through a direct interaction between PAR-6 and Pals1 (Hurd et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
11447115	The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM) Ebnet, K, Suzuki, A, Horikoshi, Y, Hirose, T, Meyer zu Brickwedde, MK, Ohno, S, Vestweber, D	EMBO J	2001
12953056	The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity Ebnet, K, Aurrand-Lions, M, Kuhn, A, Kiefer, F, Butz, S, Zander, K, Meyer zu Brickwedde, MK, Suzuki, A, Imhof, BA, Vestweber, D	J Cell Sci	2003