Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions

Stable Identifier
Homo sapiens
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PAR-3 exists in a ternary complex with aPKC and PAR-6 to form the PAR-aPKC complex (Macara, 2004; Suzuki and Ohno, 2006). This complex is critically involved in the development of Tight Junctions (TJs) from primordial spot-like Adherens Junctions (AJs) (Suzuki et al., 2002). PAR-3 directly interacts with Junctional Adhesion Molecules (JAM)-A, -B, and -C (Ebnet et al., 2001; Ebnet et al., 2004).The interaction with JAM-A might anchor the PAR-aPKC complex to TJs but might also be necessary to recruit the PAR-aPKC complex to primordial spot-like AJs where it becomes activated in response to cell-cell adhesion (reviewed in (Ebnet et al., 2008). The PAR-aPKC complex might also be physically linked to the second polarity protein complex at TJs, the CRB3-Pals1-PATJ complex through a direct interaction between PAR-6 and Pals1 (Hurd et al., 2003).

Literature References
PubMed ID Title Journal Year
12953056 The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

Imhof, BA, Meyer zu Brickwedde, MK, Butz, S, Aurrand-Lions, M, Zander, K, Kuhn, A, Ebnet, K, Kiefer, F, Vestweber, D, Suzuki, A

J Cell Sci 2003
11447115 The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

Ohno, S, Meyer zu Brickwedde, MK, Ebnet, K, Vestweber, D, Hirose, T, Horikoshi, Y, Suzuki, A

EMBO J 2001
Orthologous Events
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