Reactome | Interaction of Nectins with Afadin

Interaction of Nectins with Afadin

Stable Identifier

R-HSA-419003

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Nectins are immunoglobulin-like cell adhesion molecules comprising a family of four members, nectin 1 - 4 (Takai and Nakanishi, 2003). In contrast to classical cadherins which interact only homophilically, nectins undergo trans-homophilic and trans-heterophilic interactions with nectins and nectin-like molecules (Takai et al., 2008b). Nectins cooperate with cadherins in regulating the formation of adherens junctions (AJs) and the strength of cell-cell adhesion. Nectins are linked to the underlying actin cytoskeleton through their interaction with the actin-binding protein Afadin (Takai et al., 2008a). Nectin-based cell–cell adhesions contribute to formation of many types of cell-cell junctions including AJs, tight junctions, and synaptic junctions.

Literature References

PubMed ID	Title	Journal	Year
10225955	Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein Takahashi, K, Nakanishi, H, Miyahara, M, Mandai, K, Satoh, K, Satoh, A, Nishioka, H, Aoki, J, Nomoto, A, Mizoguchi, A, Takai, Y	J Cell Biol	1999