A1 and A3 receptors bind adenosine

Stable Identifier
Reaction [binding]
Homo sapiens
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The A1 receptor (Libert F et al, 1992) has an inhibitory function on most of the tissues in which it is expressed. In the brain, it slows metabolic activity and also decreases heart rate. The A1, together with A2a receptors, are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow.
The A3 receptor (Salvatore CA et al, 1993) mediates a sustained cardioprotective function during cardiac ischemia and it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury.
Both the A1 and A3 receptors mediate their effects by coupling with the G protein alpha i subunit which inhibits adenylyl cyclase (Wise A et al, 1999).
Literature References
PubMed ID Title Journal Year
10029519 Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins

Lee, M, Sheehan, M, Wise, A, Rees, S, Milligan, G

Biochemistry 1999
1530647 Cloning and functional characterization of a human A1 adenosine receptor

Ensinger, HA, Mendla, KD, Dumont, JE, Czernilofsky, A, Van Sande, J, Vassart, G, Lefort, A, Libert, F

Biochem Biophys Res Commun 1992
8234299 Molecular cloning and characterization of the human A3 adenosine receptor

Jacobson, MA, Linden, J, Salvatore, CA, Johnson, RG, Taylor, HE

Proc Natl Acad Sci U S A 1993
Orthologous Events
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