Reactome | A1 and A3 receptors bind adenosine

A1 and A3 receptors bind adenosine

Stable Identifier

R-HSA-418904

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Nucleotide-like (purinergic) receptors (Homo sapiens)
        
        Adenosine P1 receptors (Homo sapiens)
        
        A1 and A3 receptors bind adenosine (Homo sapiens)

General

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The A1 receptor (Libert F et al, 1992) has an inhibitory function on most of the tissues in which it is expressed. In the brain, it slows metabolic activity and also decreases heart rate. The A1, together with A2a receptors, are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow.
The A3 receptor (Salvatore CA et al, 1993) mediates a sustained cardioprotective function during cardiac ischemia and it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury.
Both the A1 and A3 receptors mediate their effects by coupling with the G protein alpha i subunit which inhibits adenylyl cyclase (Wise A et al, 1999).

Literature References

PubMed ID	Title	Journal	Year
10029519	Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins Wise, A, Sheehan, M, Rees, S, Lee, M, Milligan, G	Biochemistry	1999
1530647	Cloning and functional characterization of a human A1 adenosine receptor Libert, F, Van Sande, J, Lefort, A, Czernilofsky, A, Dumont, JE, Vassart, G, Ensinger, HA, Mendla, KD	Biochem Biophys Res Commun	1992
8234299	Molecular cloning and characterization of the human A3 adenosine receptor Salvatore, CA, Jacobson, MA, Taylor, HE, Linden, J, Johnson, RG	Proc Natl Acad Sci U S A	1993