Plexin-B1 activates RhoA and induces growth cone collapse and and cytoskeletal reorganization through Rho-specific guanine nucleotide exchange factors PDZ-RhoGEF (ARHGEF11) and leukemia-associated RhoGEF (LARG, ARHGEF12). Plexin-B1 directly interacts with PDZ-RhoGEF through its c-terminal PDZ domain binding motif. It has been suggested that Rnd1, which binds to the cytoplasmic part of plexin-B1, can promote the interaction between plexin-B1 and PDZ-RhoGEF. The PDZ domain of LARG is directly involved in the interaction with the c-terminal sequence of Plexin-B1.
Guan, KL, Vikis, HG, Aurandt, J, Ahn, N, Gutkind, JS
Offermanns, S, Kuner, R, Swiercz, JM
Katoh, H, Oinuma, I, Negishi, M, Harada, A
Furuyama, T, Kogo, M, Matsuya, T, Inagaki, S, Yamamoto, T, Hirotani, M, Ohoka, Y, Nirasawa, H
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