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SERPINE2 [extracellular region]
Stable Identifier
R-HSA-4127459
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Glia-derived nexin, GDN_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)
SERPINE1-like proteins [extracellular region] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)
SERPINE1-like proteins [extracellular region] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
factor V -> factor Va + factor V activation peptide (Homo sapiens)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
SERPINE2:GAG [plasma membrane] (Homo sapiens)
SERPINE2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07093 SERPINE2
Gene Names
SERPINE2, PI7, PN1
Chain
signal peptide:1-19, chain:20-398
Reference Genes
BioGPS Gene:5270 SERPINE2
COSMIC (genes):SERPINE2 SERPINE2
CTD Gene:5270 SERPINE2
dbSNP Gene:5270 SERPINE2
ENSEMBL:ENSG00000135919 SERPINE2
HGNC:8951 SERPINE2
KEGG:hsa:5270 SERPINE2
Monarch:5270 SERPINE2
NCBI Gene:5270 SERPINE2
OMIM:177010 SERPINE2
UCSC:P07093 SERPINE2
Reference Transcript
RefSeq:NM_001136530.1 SERPINE2
RefSeq:NM_001136528.1 SERPINE2
RefSeq:XM_017004332.1 SERPINE2
RefSeq:NM_006216.3 SERPINE2
RefSeq:XM_017004329.1 SERPINE2
RefSeq:XM_017004330.1 SERPINE2
RefSeq:XM_017004331.1 SERPINE2
Other Identifiers
11741678_a_at
11741679_x_at
11741680_a_at
11757442_a_at
11757643_x_at
11758598_s_at
16909021
212190_PM_at
212190_at
2601418
2601419
2601420
2601421
2601422
2601423
2601424
2601425
2601426
2601427
2601428
2601429
2601430
2601431
2601432
2601438
2601442
2601447
2601448
2601449
2601450
2601453
2601459
2601460
2601461
2601462
2601463
41246_at
5270
8059376
A_23_P50919
GE88673
GE899558
GO:0004867
GO:0005102
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005829
GO:0007399
GO:0007596
GO:0008201
GO:0008285
GO:0009611
GO:0010544
GO:0010757
GO:0010766
GO:0010955
GO:0021683
GO:0022414
GO:0030154
GO:0030163
GO:0030168
GO:0030195
GO:0030308
GO:0030312
GO:0030334
GO:0031012
GO:0031091
GO:0031410
GO:0031594
GO:0032940
GO:0033363
GO:0042177
GO:0042628
GO:0043226
GO:0045861
GO:0045879
GO:0048505
GO:0048711
GO:0048856
GO:0050974
GO:0051898
GO:0051966
GO:0060291
GO:0060384
GO:0061108
GO:0062023
GO:0090331
GO:0098772
GO:1903561
HMNXSV003058374
Hs.21858.2.A1_3p_at
ILMN_1655595
PH_hs_0001899
PH_hs_0035162
TC02002823.hg
Participates
as a component of
SERPINE2:GAG [plasma membrane] (Homo sapiens)
as a candidate of
SERPINE1-like proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
SERPINE2 [plasma membrane]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
Homologues of SERPINE2 [extracellular region]
(Caenorhabditis elegans)
Homologues of SERPINE2 [extracellular region]
(Drosophila melanogaster)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
Spn27A [extracellular region]
(Drosophila melanogaster)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Acp76A [extracellular region]
(Drosophila melanogaster)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
serpine2 [extracellular region]
(Danio rerio)
serpine2 [extracellular region]
(Xenopus tropicalis)
srp-8 [extracellular region]
(Caenorhabditis elegans)
SERPINE2 [extracellular region]
(Bos taurus)
SERPINE2 [extracellular region]
(Caenorhabditis elegans)
SERPINE2 [extracellular region]
(Canis familiaris)
SERPINE2 [extracellular region]
(Gallus gallus)
SERPINE2 [extracellular region]
(Sus scrofa)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
Serpine2 [extracellular region]
(Mus musculus)
Serpine2 [extracellular region]
(Rattus norvegicus)
srp-7 [extracellular region]
(Caenorhabditis elegans)
Spn42Db [extracellular region]
(Drosophila melanogaster)
Spn75F [extracellular region]
(Drosophila melanogaster)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
nec [extracellular region]
(Drosophila melanogaster)
Spn31A [extracellular region]
(Drosophila melanogaster)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
srp-1 [extracellular region]
(Caenorhabditis elegans)
Spn38F [extracellular region]
(Drosophila melanogaster)
srp-3 [extracellular region]
(Caenorhabditis elegans)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
Spn42De [extracellular region]
(Drosophila melanogaster)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn85F [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001130002.1
,
XP_016859820.1
,
NP_006207.1
,
XP_016859819.1
,
XP_016859821.1
,
XP_016859818.1
,
NP_001130000.1
ENSEMBL
ENSP00000386969
,
ENST00000258405
,
ENSP00000415786
,
ENSP00000386412
,
ENSP00000258405
,
ENST00000409304
,
ENST00000409840
,
ENST00000447280
OpenTargets
ENSG00000135919
HPA
ENSG00000135919-SERPINE2
PRO
P07093
Pharos - Targets
P07093
GlyGen
P07093
PDB
4DY0
,
4DY7
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