Ras:GTP binds p120-RasGAP

Stable Identifier
R-HSA-4093331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ras:GTP binds p120-RasGAP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p120-RasGAP (RASA1) binds to activated Ras (Ras:GTP) through its GAP-related catalytic domain, which is sufficient for stimulating the Ras GTPase activity. p120-RasGAP accelerates the intrinsic GTPase activity of Ras to promote Ras inactivation (Yao et al. 1995).

Literature References
PubMed ID Title Journal Year
2201922 Suppression of c-ras transformation by GTPase-activating protein

Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR

Nature 1990
7478585 Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells

Yao, R, Cooper, GM

Oncogene 1995
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Orthologous Events
Ras:GTP binds p120-RasGAP (Canis familiaris)
Ras:GTP binds p120-RasGAP (Danio rerio)
Ras:GTP binds p120-RasGAP (Gallus gallus)
Ras:GTP binds p120-RasGAP (Mus musculus)
Ras:GTP binds p120-RasGAP (Rattus norvegicus)
Ras:GTP binds p120-RasGAP (Sus scrofa)
Ras:GTP binds p120-RasGAP (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-08-14)