Ras:GTP binds p120-RasGAP

Stable Identifier
R-HSA-4093331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Ras:GTP binds p120-RasGAP
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p120-RasGAP (RASA1) binds to activated Ras (Ras:GTP) through its GAP-related catalytic domain, which is sufficient for stimulating the Ras GTPase activity. p120-RasGAP accelerates the intrinsic GTPase activity of Ras to promote Ras inactivation (Yao et al. 1995).

Literature References
PubMed ID Title Journal Year
2201922 Suppression of c-ras transformation by GTPase-activating protein

Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR

Nature 1990
7478585 Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells

Yao, R, Cooper, GM

Oncogene 1995
Participants
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Participant Of
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Orthologous Events
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Ras:GTP binds p120-RasGAP (Sus scrofa)
Ras:GTP binds p120-RasGAP (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-08-14)
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