Ras:GTP binds p120-RasGAP

Stable Identifier
R-HSA-4093331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Ras:GTP binds p120-RasGAP
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p120-RasGAP (RASA1) binds to activated Ras (Ras:GTP) through its GAP-related catalytic domain, which is sufficient for stimulating the Ras GTPase activity. p120-RasGAP accelerates the intrinsic GTPase activity of Ras to promote Ras inactivation (Yao et al. 1995).

Literature References
PubMed ID Title Journal Year
7478585 Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells

Cooper, GM, Yao, R

Oncogene 1995
2201922 Suppression of c-ras transformation by GTPase-activating protein

DeClue, JE, McCormick, F, Zhang, K, Lowy, DR, Papageorge, AG, Vass, WC

Nature 1990
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Orthologous Events
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Ras:GTP binds p120-RasGAP (Sus scrofa)
Ras:GTP binds p120-RasGAP (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-08-14)
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