PIAS1,2-1 SUMOylates AR with SUMO1

Stable Identifier
R-HSA-4090390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1,2-1 SUMOylate AR at lysine-386 and lysine-520 with SUMO1 (Poukka et al. 2000, Kotaja et al. 2002, Nishida and Yasuda 2002). SUMOylation reduces transcription activation by AR.

Literature References
PubMed ID Title Journal Year
11121022 Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)

Poukka, H, Karvonen, U, Janne, OA, Palvimo, JJ

Proc. Natl. Acad. Sci. U.S.A. 2000
12177000 PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription

Nishida, T, Yasuda, H

J. Biol. Chem. 2002
12077349 PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases

Kotaja, N, Karvonen, U, Jänne, OA, Palvimo, JJ

Mol. Cell. Biol. 2002
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS1,2-1 [nucleoplasm]

Orthologous Events
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