PIAS1,2-1 SUMOylates AR with SUMO1

Stable Identifier
R-HSA-4090390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1,2-1 SUMOylates AR with SUMO1
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PIAS1,2-1 SUMOylate AR at lysine-386 and lysine-520 with SUMO1 (Poukka et al. 2000, Kotaja et al. 2002, Nishida and Yasuda 2002). SUMOylation reduces transcription activation by AR.
Literature References
PubMed ID Title Journal Year
12177000 PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription

Nishida, T, Yasuda, H

J. Biol. Chem. 2002
11121022 Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)

Poukka, H, Karvonen, U, Janne, OA, Palvimo, JJ

Proc. Natl. Acad. Sci. U.S.A. 2000
12077349 PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases

Kotaja, N, Karvonen, U, Jänne, OA, Palvimo, JJ

Mol. Cell. Biol. 2002
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS1,2-1 [nucleoplasm]

Physical Entity
PIAS1,2-1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,2-1 SUMOylates AR with SUMO1 (Bos taurus)
PIAS1,2-1 SUMOylates AR with SUMO1 (Danio rerio)
PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)
PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)
PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)
PIAS1,2-1 SUMOylates AR with SUMO1 (Sus scrofa)
Authored
May, B  (2013-08-07)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-14)
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