Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Stable Identifier
Reaction [binding]
Homo sapiens
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Endostatin binds to the integrins alphaVbeta3, alphaVbeta5, alpha5beta1 (Rehn et al. 2001, Faye et al. 2009) and alpha3beta1 (Su et al. 2012). Endostatin is the cleaved non-collagenous C ternminal domain of collagen alpha-1(XVIII) a member of the multiplexin family. It inhibits endothelial cell migration, proliferation, and angiogenesis (Fu et al. 2009).

Literature References
PubMed ID Title Journal Year
22884367 Target-derived matricryptins organize cerebellar synapse formation through ?3?1 integrins

Su, J, Stenbjorn, RS, Gorse, K, Su, K, Hauser, KF, Ricard-Blum, S, Pihlajaniemi, T, Fox, MA

Cell Rep 2012
19502598 Molecular interplay between endostatin, integrins, and heparan sulfate

Faye, C, Moreau, C, Chautard, E, Jetne, R, Fukai, N, Ruggiero, F, Humphries, MJ, Olsen, BR, Ricard-Blum, S

J. Biol. Chem. 2009
11158588 Interaction of endostatin with integrins implicated in angiogenesis

Rehn, M, Veikkola, T, Kukk-Valdre, E, Nakamura, H, Ilmonen, M, Lombardo, C, Pihlajaniemi, T, Alitalo, K, Vuori, K

Proc. Natl. Acad. Sci. U.S.A. 2001
Participant Of
Orthologous Events
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