Reactome | Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Stable Identifier

R-HSA-4088264

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

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Endostatin binds to the integrins alphaVbeta3, alphaVbeta5, alpha5beta1 (Rehn et al. 2001, Faye et al. 2009) and alpha3beta1 (Su et al. 2012). Endostatin is the cleaved non-collagenous C ternminal domain of collagen alpha-1(XVIII) a member of the multiplexin family. It inhibits endothelial cell migration, proliferation, and angiogenesis (Fu et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
22884367	Target-derived matricryptins organize cerebellar synapse formation through ?3?1 integrins Su, J, Stenbjorn, RS, Gorse, K, Su, K, Hauser, KF, Ricard-Blum, S, Pihlajaniemi, T, Fox, MA	Cell Rep	2012
19502598	Molecular interplay between endostatin, integrins, and heparan sulfate Faye, C, Moreau, C, Chautard, E, Jetne, R, Fukai, N, Ruggiero, F, Humphries, MJ, Olsen, BR, Ricard-Blum, S	J. Biol. Chem.	2009
11158588	Interaction of endostatin with integrins implicated in angiogenesis Rehn, M, Veikkola, T, Kukk-Valdre, E, Nakamura, H, Ilmonen, M, Lombardo, C, Pihlajaniemi, T, Alitalo, K, Vuori, K	Proc. Natl. Acad. Sci. U.S.A.	2001