Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Stable Identifier
R-HSA-4088264
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Endostatin binds to the integrins alphaVbeta3, alphaVbeta5, alpha5beta1 (Rehn et al. 2001, Faye et al. 2009) and alpha3beta1 (Su et al. 2012). Endostatin is the cleaved non-collagenous C ternminal domain of collagen alpha-1(XVIII) a member of the multiplexin family. It inhibits endothelial cell migration, proliferation, and angiogenesis (Fu et al. 2009).

Literature References
PubMed ID Title Journal Year
19502598 Molecular interplay between endostatin, integrins, and heparan sulfate

Moreau, C, Olsen, BR, Ruggiero, F, Chautard, E, Humphries, MJ, Jetne, R, Faye, C, Ricard-Blum, S, Fukai, N

J. Biol. Chem. 2009
22884367 Target-derived matricryptins organize cerebellar synapse formation through ?3?1 integrins

Stenbjorn, RS, Pihlajaniemi, T, Gorse, K, Su, J, Fox, MA, Su, K, Ricard-Blum, S, Hauser, KF

Cell Rep 2012
11158588 Interaction of endostatin with integrins implicated in angiogenesis

Rehn, M, Pihlajaniemi, T, Veikkola, T, Lombardo, C, Kukk-Valdre, E, Alitalo, K, Ilmonen, M, Nakamura, H, Vuori, K

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!