Reactome | Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

Stable Identifier

R-HSA-4088264

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1

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Endostatin binds to the integrins alphaVbeta3, alphaVbeta5, alpha5beta1 (Rehn et al. 2001, Faye et al. 2009) and alpha3beta1 (Su et al. 2012). Endostatin is the cleaved non-collagenous C ternminal domain of collagen alpha-1(XVIII) a member of the multiplexin family. It inhibits endothelial cell migration, proliferation, and angiogenesis (Fu et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19502598	Molecular interplay between endostatin, integrins, and heparan sulfate Faye, C, Moreau, C, Chautard, E, Jetne, R, Fukai, N, Ruggiero, F, Humphries, MJ, Olsen, BR, Ricard-Blum, S	J. Biol. Chem.	2009
22884367	Target-derived matricryptins organize cerebellar synapse formation through ?3?1 integrins Su, J, Stenbjorn, RS, Gorse, K, Su, K, Hauser, KF, Ricard-Blum, S, Pihlajaniemi, T, Fox, MA	Cell Rep	2012
11158588	Interaction of endostatin with integrins implicated in angiogenesis Rehn, M, Veikkola, T, Kukk-Valdre, E, Nakamura, H, Ilmonen, M, Lombardo, C, Pihlajaniemi, T, Alitalo, K, Vuori, K	Proc. Natl. Acad. Sci. U.S.A.	2001