Reactome | Plasma membrane glycoconjugates translocate to the cytosol

Plasma membrane glycoconjugates translocate to the cytosol

Stable Identifier

R-HSA-4088205

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        Plasma membrane glycoconjugates translocate to the cytosol (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Plasma membrane glycoconjugates translocate to the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycoconjugates have to translocate to the cytosol for degradation by cytosol-specific sialidase 2 (NEU2). The mechanism of translocation is unknown but could simply be by diffusion (Li & Chen 2012).

Literature References

PubMed ID	Title	Journal	Year
22526796	Sialic acid metabolism and sialyltransferases: natural functions and applications Li, Y, Chen, X	Appl. Microbiol. Biotechnol.	2012

Participants

Input

glycoconjugates [plasma membrane]

Output

glycoconjugates [cytosol]

Participant Of

hasEvent

Sialic acid metabolism

Authored

Jassal, B (2013-08-12)

Reviewed

Medrano, JF (2014-01-08)

Wickramasinghe, S (2014-01-08)

Created

Jassal, B (2013-08-12)