SUMOylation of UBE2I with SUMO1

Stable Identifier
R-HSA-4085350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of UBE2I with SUMO1
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UBE2I (UBC9) is SUMOylated at lysine-14 with SUMO1 (Knipscheer et al. 2008). SUMOylation alters the target specificity of UBE2I, decreasing its SUMOylation activity towards RanGAP1 and increasing it towards SP100.
Literature References
PubMed ID Title Journal Year
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Knipscheer, P, Flotho, A, Klug, H, Olsen, JV, van Dijk, WJ, Fish, A, Johnson, ES, Mann, M, Sixma, TK, Pichler, A

Mol. Cell 2008
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Output
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Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of UBE2I with SUMO1 (Bos taurus)
SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)
SUMOylation of UBE2I with SUMO1 (Danio rerio)
SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)
SUMOylation of UBE2I with SUMO1 (Gallus gallus)
SUMOylation of UBE2I with SUMO1 (Mus musculus)
SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)
SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)
SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)
SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)
SUMOylation of UBE2I with SUMO1 (Sus scrofa)
Authored
May, B  (2013-08-03)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-05)
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