NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate

Stable Identifier
R-HSA-4085217
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate
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Once in the cytosol, sialic acids are either reutilized or degraded. N-acetylneuraminate lyase (NPL) is a cytosolic, tetrameric enzyme that can cleave the major sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) to form N-acetylmannosamine (ManNAc) and N-glycolylmannosamine (ManNGc) respectively (Wu et al. 2005). Although humans cannot form Neu5Gc due to a non-functional CMAHP enzyme, Neu5Gc can be ingested by dietary means and must therefore be degraded to avoid accumulation of this immunoreactive sialic acid (Bergfeld et al. 2012).
Literature References
PubMed ID Title Journal Year
22692205 Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid

Bergfeld, AK, Pearce, OM, Diaz, SL, Pham, T, Varki, A

J. Biol. Chem. 2012
16147865 A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte

Wu, M, Gu, S, Xu, J, Zou, X, Zheng, H, Jin, Z, Xie, Y, Ji, C, Mao, Y

DNA Seq. 2005
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Catalyst Activity

N-acetylneuraminate lyase activity of NPL tetramer [cytosol]

Physical Entity
NPL tetramer [cytosol] (Homo sapiens)
Activity
N-acetylneuraminate lyase activity (GO:0008747)
Orthologous Events
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Bos taurus)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Gallus gallus)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Mus musculus)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Rattus norvegicus)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)
NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)
Authored
Jassal, B  (2013-08-02)
Reviewed
Medrano, JF  (2014-01-08)
Wickramasinghe, S  (2014-01-08)
Created
Jassal, B  (2013-08-02)
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