Canstatin binds integrins alphaVbeta3, alphaVbeta5

Stable Identifier
R-HSA-4085087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Canstatin is the non-collagenous C-terminal domain of alpha-2(IV) collagen. It is an inhibitor of endothelial and tumor cells via mitochondrial damage initiated through an interaction with integrins alphaVbeta3 and alphaVbeta5 (Magnon et al. 2005).

Literature References
PubMed ID Title Journal Year
15899827 Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins

Magnon, C, Galaup, A, Mullan, B, Rouffiac, V, Bouquet, C, Bidart, JM, Griscelli, F, Opolon, P, Perricaudet, M

Cancer Res. 2005
Participants
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Orthologous Events
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Created