Reactome | Canstatin binds integrins alphaVbeta3, alphaVbeta5

Canstatin binds integrins alphaVbeta3, alphaVbeta5

Stable Identifier

R-HSA-4085087

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Canstatin binds integrins alphaVbeta3, alphaVbeta5

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Canstatin is the non-collagenous C-terminal domain of alpha-2(IV) collagen. It is an inhibitor of endothelial and tumor cells via mitochondrial damage initiated through an interaction with integrins alphaVbeta3 and alphaVbeta5 (Magnon et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15899827	Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins Galaup, A, Perricaudet, M, Bouquet, C, Opolon, P, Bidart, JM, Magnon, C, Griscelli, F, Rouffiac, V, Mullan, B	Cancer Res.	2005