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Laminin-111 binds endostatin dimer
Stable Identifier
R-HSA-4084507
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Extracellular matrix organization (Homo sapiens)
Laminin interactions (Homo sapiens)
Laminin-111 binds endostatin dimer (Homo sapiens)
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Endostatin is an anti-angiogenic and motility-inducing factor produced by proteolytic cleavage within the NC1 domain of collagen type XVIII. It is bound by all three short arms of laminin-111 (Javaherian et al. 2002). Laminin-111 complexes strongly with the NC1 trimeric domain or endostatin dimer, but only weakly with endostatin monomer.
Literature References
PubMed ID
Title
Journal
Year
12237301
Laminin modulates morphogenic properties of the collagen XVIII endostatin domain
LaMontagne, KR
,
Javaherian, K
,
Lo, KM
,
Park, SY
,
Gillies, S
,
Pickl, WF
,
Sjin, RT
J. Biol. Chem.
2002
Participants
Input
Endostatin dimer [extracellular region]
(Homo sapiens)
Laminin-111 [extracellular region]
(Homo sapiens)
Output
Laminin-111:Endostatin dimer [extracellular region]
(Homo sapiens)
Participates
as an event of
Laminin interactions (Homo sapiens)
Authored
Jupe, S (2012-08-08)
Reviewed
Ricard-Blum, S (2013-08-13)
Created
Jupe, S (2013-07-29)
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