Reactome | PPARA:RXRA binds Corepressors of PPARA

PPARA:RXRA binds Corepressors of PPARA

Stable Identifier

R-HSA-400183

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.

Literature References

PubMed ID	Title	Journal	Year
16503871	Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis Gouni-Berthold, I, Krone, W	Curr Drug Targets Cardiovasc Haematol Disord	2005
16476485	From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions Gelman, L, Wahli, W, Michalik, L, Desvergne, B, Feige, JN	Prog Lipid Res	2006
10529898	Peroxisome proliferator-activated receptors: nuclear control of metabolism Wahli, W, Desvergne, B	Endocr Rev	1999
11330046	Peroxisome proliferator-activated receptors, coactivators, and downstream targets Qi, C, Reddy, JK, Zhu, Y	Cell Biochem Biophys	2000
18288277	Peroxisome proliferator activated receptors and lipoprotein metabolism Kersten, S	PPAR Res	2008
18292238	A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin Shen, P, Husna, B, Tai, ES, Liu, MH, Yong, EL, Li, J	Mol Endocrinol	2008