PPARA:RXRA binds Corepressors of PPARA

Stable Identifier
R-HSA-400183
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PPARA:RXRA binds Corepressors of PPARA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the absence of activating ligands of PPAR-alpha, the PPAR-alpha:RXR-alpha heterodimers recruit corepressors NCoR1, NCoR2(SMRT), and histone deacetylases (HDACs) to genes regulated by PPAR-alpha. The corepressors maintain chromatin at the gene in an inactive conformation and prevent expression of the gene.
Literature References
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of transcription initiation by RNA polymerase II (0060633)
Catalyst Activity

transcription corepressor activity of Corepressors of PPARalpha [nucleoplasm]

Physical Entity
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
Activity
transcription corepressor activity (GO:0003714)
Orthologous Events
PPARA:RXRA binds Corepressors of PPARA (Bos taurus)
PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)
PPARA:RXRA binds Corepressors of PPARA (Danio rerio)
PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)
PPARA:RXRA binds Corepressors of PPARA (Gallus gallus)
PPARA:RXRA binds Corepressors of PPARA (Mus musculus)
PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)
PPARA:RXRA binds Corepressors of PPARA (Sus scrofa)
PPARA:RXRA binds Corepressors of PPARA (Xenopus tropicalis)
Authored
May, B  (2009-05-30)
Reviewed
Kersten, S  (2009-06-08)
Hill, DP  (2025-08-13)
Created
May, B  (2009-03-24)
Cite Us!