Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The pancreatic beta cell contains Alpha2A and Alpha2C Adrenergic Receptors. These are G-protein coupled receptors that can bind either adrenaline or noradrenaline.
Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
8277227 Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans

Scarpello, JH, London, NJ, Morgan, NG, Cable, HC, James, RF, Lacey, RJ

J Endocrinol 1993
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S

Eur J Endocrinol 2003
8778232 Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans

Scarpello, JH, Perrett, CW, Morgan, NG, Chan, SL, Cable, HC, James, RF, Lacey, RJ

J Endocrinol 1996
9760042 Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors

Scheinin, M, Pihlavisto, M, Peltonen, JM

Eur J Pharmacol 1998
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
10948191 An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

Forbes, SL, Small, KM, Liggett, SB, Brown, KM

J Biol Chem 2000
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Straub, SG, Fang, Q, Sharp, GW, Zhao, Y

J Biol Chem 2008
Catalyst Activity

alpha2-adrenergic receptor activity of ADRA2A,C [plasma membrane]

Orthologous Events
Cite Us!