Reactome | Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

Stable Identifier

R-HSA-400071

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

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The pancreatic beta cell contains Alpha2A and Alpha2C Adrenergic Receptors. These are G-protein coupled receptors that can bind either adrenaline or noradrenaline.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I	EMBO J	1995
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
8277227	Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans Scarpello, JH, London, NJ, Morgan, NG, Cable, HC, James, RF, Lacey, RJ	J Endocrinol	1993
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S	Eur J Endocrinol	2003
8778232	Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans Scarpello, JH, Perrett, CW, Morgan, NG, Chan, SL, Cable, HC, James, RF, Lacey, RJ	J Endocrinol	1996
9760042	Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors Scheinin, M, Pihlavisto, M, Peltonen, JM	Eur J Pharmacol	1998
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Ahren, B, Winzell, MS	Pharmacol Ther	2007
10948191	An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling Forbes, SL, Small, KM, Liggett, SB, Brown, KM	J Biol Chem	2000
18162464	Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel Straub, SG, Fang, Q, Sharp, GW, Zhao, Y	J Biol Chem	2008