Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

Stable Identifier
R-HSA-400071
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The pancreatic beta cell contains Alpha2A and Alpha2C Adrenergic Receptors. These are G-protein coupled receptors that can bind either adrenaline or noradrenaline.

Literature References
PubMed ID Title Journal Year
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Lang, J, Nishimoto, I, Okamoto, T, Regazzi, R, Kiraly, C, Weller, U, Wollheim, CB

EMBO J 1995
8277227 Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans

Lacey, RJ, Cable, HC, James, RF, London, NJ, Scarpello, JH, Morgan, NG

J Endocrinol 1993
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Peterhoff, M, Sieg, A, Brede, M, Chao, CM, Hein, L, Ullrich, S

Eur J Endocrinol 2003
8778232 Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans

Lacey, RJ, Chan, SL, Cable, HC, James, RF, Perrett, CW, Scarpello, JH, Morgan, NG

J Endocrinol 1996
9760042 Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors

Peltonen, JM, Pihlavisto, M, Scheinin, M

Eur J Pharmacol 1998
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
18162464 Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel

Zhao, Y, Fang, Q, Straub, SG, Sharp, GW

J Biol Chem 2008
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