Reactome | L-type Calcium Channels close in pancreatic beta cells

L-type Calcium Channels close in pancreatic beta cells

Stable Identifier

R-HSA-400046

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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L-type Calcium Channels close in pancreatic beta cells

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Closing (inhibition) of the L-type calcium channels in the plasma membrane prevents the flow of calcium ions across the membrane.

Literature References

PubMed ID	Title	Journal	Year
7641683	Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits Lang, J, Nishimoto, I, Okamoto, T, Regazzi, R, Kiraly, C, Weller, U, Wollheim, CB	EMBO J	1995
8997178	Mechanisms of inhibition of insulin release Sharp, GW	Am J Physiol	1996
14514350	Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice Peterhoff, M, Sieg, A, Brede, M, Chao, CM, Hein, L, Ullrich, S	Eur J Endocrinol	2003
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Winzell, MS, Ahren, B	Pharmacol Ther	2007