L-type Calcium Channels close in pancreatic beta cells

Stable Identifier
R-HSA-400046
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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L-type Calcium Channels close in pancreatic beta cells
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Closing (inhibition) of the L-type calcium channels in the plasma membrane prevents the flow of calcium ions across the membrane.
Literature References
PubMed ID Title Journal Year
7641683 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Okamoto, T, Regazzi, R, Kiraly, C, Lang, J, Weller, U, Wollheim, CB, Nishimoto, I

EMBO J 1995
8997178 Mechanisms of inhibition of insulin release

Sharp, GW

Am J Physiol 1996
14514350 Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice

Chao, CM, Brede, M, Hein, L, Sieg, A, Peterhoff, M, Ullrich, S

Eur J Endocrinol 2003
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
G-beta:G-gamma (candidates) [plasma membrane] (Homo sapiens)
Inferred From
Closing of L-type Calcium Channels (rat) (Rattus norvegicus)
Authored
May, B  (2009-05-27)
Reviewed
D'Eustachio, P  (2009-06-02)
Created
May, B  (2009-03-24)
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